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犬头颈癌的临床兽医硼中子俘获疗法（BNCT）研究：弥合转化研究与临床研究之间的差距

Clinical Veterinary Boron Neutron Capture Therapy (BNCT) Studies in Dogs with Head and Neck Cancer: Bridging the Gap between Translational and Clinical Studies.

作者信息

Schwint Amanda E, Monti Hughes Andrea, Garabalino Marcela A, Santa Cruz Gustavo A, González Sara J, Longhino Juan, Provenzano Lucas, Oña Paulina, Rao Monica, Cantarelli María de Los Ángeles, Leiras Andrea, Olivera María Silvina, Trivillin Verónica A, Alessandrini Paula, Brollo Fabricio, Boggio Esteban, Costa Hernan, Ventimiglia Romina, Binia Sergio, Pozzi Emiliano C C, Nievas Susana I, Santa Cruz Iara S

机构信息

National Atomic Energy Commission (CNEA), Avenida del Libertador 8250, C1429 BNP, Buenos Aires, Argentina.

National Research Council (CONICET), Godoy Cruz 2290, C1425FQB, Buenos Aires, Argentina.

出版信息

Biology (Basel). 2020 Oct 7;9(10):327. doi: 10.3390/biology9100327.

DOI:10.3390/biology9100327
PMID:33036386
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7599538/
Abstract

Translational Boron Neutron Capture Therapy (BNCT) studies performed by our group and clinical BNCT studies worldwide have shown the therapeutic efficacy of BNCT for head and neck cancer. The present BNCT studies in veterinary patients with head and neck cancer were performed to optimize the therapeutic efficacy of BNCT, contribute towards exploring the role of BNCT in veterinary medicine, put in place technical aspects for an upcoming clinical trial of BNCT for head and neck cancer at the RA-6 Nuclear Reactor, and assess the feasibility of employing the existing B2 beam to treat large, deep-seated tumors. Five dogs with head and neck cancer with no other therapeutic option were treated with two applications of BNCT mediated by boronophenyl-alanine (BPA) separated by 3-5 weeks. Two to three portals per BNCT application were used to achieve a potentially therapeutic dose over the tumor without exceeding normal tissue tolerance. Clinical and Computed Tomography results evidenced partial tumor control in all cases, with slight-moderate mucositis, excellent life quality, and prolongation in the survival time estimated at recruitment. These exploratory studies show the potential value of BNCT in veterinary medicine and contribute towards initiating a clinical BNCT trial for head and neck cancer at the RA-6 clinical facility.

摘要

我们团队开展的硼中子俘获疗法（BNCT）转化研究以及全球范围内的BNCT临床研究均已表明，BNCT对头颈部癌症具有治疗效果。目前针对患有头颈部癌症的兽医患者开展BNCT研究，目的是优化BNCT的治疗效果，助力探索BNCT在兽医学中的作用，为即将在RA - 6核反应堆开展的头颈部癌症BNCT临床试验落实技术环节，并评估利用现有的B2束治疗大型深部肿瘤的可行性。对五只没有其他治疗选择的头颈部癌症犬进行了两次BNCT治疗，两次治疗使用硼苯丙氨酸（BPA）介导，间隔3 - 5周。每次BNCT治疗使用两到三个照射野，以在不超过正常组织耐受剂量的情况下，使肿瘤获得潜在的治疗剂量。临床和计算机断层扫描结果证明，所有病例的肿瘤均得到部分控制，伴有轻度至中度粘膜炎，生活质量良好，且生存期较招募时估计有所延长。这些探索性研究表明了BNCT在兽医学中的潜在价值，并有助于在RA - 6临床机构启动头颈部癌症的BNCT临床试验。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a64f/7599538/bc4147f452a9/biology-09-00327-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a64f/7599538/6260eeb128a6/biology-09-00327-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a64f/7599538/c68402aaddd6/biology-09-00327-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a64f/7599538/af11ccdbd80c/biology-09-00327-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a64f/7599538/bc4147f452a9/biology-09-00327-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a64f/7599538/6260eeb128a6/biology-09-00327-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a64f/7599538/c68402aaddd6/biology-09-00327-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a64f/7599538/af11ccdbd80c/biology-09-00327-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a64f/7599538/bc4147f452a9/biology-09-00327-g004.jpg

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