Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Via Giustiniani 2, Padua 35128, Italy.
Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Via Giustiniani 2, Padua 35128, Italy.
Cardiol Clin. 2020 Nov;38(4):589-599. doi: 10.1016/j.ccl.2020.07.004. Epub 2020 Sep 16.
To overcome the not negligible metallic drug-eluting stents adverse events rate, the polymeric or metallic bioresorbable scaffolds were designed to provide early drug delivery and mechanical support followed by complete resorption. However, the long-term evidence, focusing on the leading Absorb BVS technology, showed higher events compared with drug-eluting stents. This review discusses the lights and shadows of the current bioresorbable scaffolds according to their mechanical properties and biodegradation profile and suggests possible perspective on these technologies. Improved scaffold design and deployment techniques might mitigate early bioresorbable scaffolds risk enhancing the late benefit of complete resorption.
为了克服不可忽视的金属药物洗脱支架不良事件发生率，设计了聚合物或金属可生物吸收支架，以提供早期药物输送和机械支撑，随后完全吸收。然而，长期证据（重点关注 Absorb BVS 技术）显示，与药物洗脱支架相比，这些事件发生率更高。本综述根据机械性能和生物降解特性讨论了当前可生物吸收支架的优缺点，并对这些技术提出了可能的展望。改进支架设计和部署技术可能会降低早期可生物吸收支架的风险，提高完全吸收的晚期获益。
