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诊断病例。一名糖尿病患者出现色素沉着和有抓痕的丘疹及结节。

Case for diagnosis. Hyperpigmented and excoriated papules and nodules in a diabetic patient.

作者信息

Hasbún Catalina, Sandoval Mauricio, González-Bombardiere Sergio

机构信息

School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

Department of Dermatology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

出版信息

An Bras Dermatol. 2020 Nov-Dec;95(6):757-759. doi: 10.1016/j.abd.2020.03.015. Epub 2020 Sep 13.

DOI:10.1016/j.abd.2020.03.015
PMID:33036808
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7672397/
Abstract

Reactive perforating collagenosis is a rare perforating dermatosis clinically characterized by intensely pruritic hyperpigmented papules, plaques, and nodules with a central keratotic plug. Histopathology reveals transepidermal elimination of collagen fibers. Its pathophysiology is still under investigation, but the acquired form has been linked to systemic conditions such as diabetes mellitus and chronic kidney disease. However, it has also been described as a paraneoplastic syndrome. The authors present the case of a 65-year-old diabetic patient in which a myeloproliferative neoplasm was suspected.

摘要

反应性穿通性胶原病是一种罕见的穿通性皮肤病，临床特征为伴有中央角质栓的剧烈瘙痒性色素沉着丘疹、斑块和结节。组织病理学显示胶原纤维经表皮排出。其病理生理学仍在研究中，但后天性形式与糖尿病和慢性肾病等全身性疾病有关。然而，它也被描述为一种副肿瘤综合征。作者报告了一例65岁糖尿病患者的病例，怀疑其患有骨髓增殖性肿瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b70/7672397/52b240fef4ba/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b70/7672397/d386a246e259/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b70/7672397/94fcaa92b733/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b70/7672397/d20fe0b578ee/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b70/7672397/52b240fef4ba/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b70/7672397/d386a246e259/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b70/7672397/94fcaa92b733/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b70/7672397/d20fe0b578ee/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b70/7672397/52b240fef4ba/gr4.jpg

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本文引用的文献

1
Dermoscopy features of acquired reactive perforating collagenosis: a case series.获得性反应性穿通性胶原病的皮肤镜特征：病例系列
Dermatol Pract Concept. 2018 Oct 31;8(4):303-305. doi: 10.5826/dpc.0804a11. eCollection 2018 Oct.
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Treatment of acquired reactive perforating dermatosis - a systematic review.获得性反应性穿孔性皮肤病的治疗 - 系统评价。
J Dtsch Dermatol Ges. 2018 Jul;16(7):825-842. doi: 10.1111/ddg.13561. Epub 2018 Jun 21.
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Giant acquired reactive perforating collagenosis in a patient with diabetes mellitus and metastatic breast carcinoma.
一名患有糖尿病和转移性乳腺癌的患者出现巨大获得性反应性穿通性胶原病。
JAAD Case Rep. 2016 Jan 14;2(1):22-4. doi: 10.1016/j.jdcr.2015.11.013. eCollection 2016 Jan.
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Allopurinol in the treatment of acquired reactive perforating collagenosis.别嘌醇治疗获得性反应性穿通性胶原病。
An Bras Dermatol. 2013 Jan-Feb;88(1):94-7. doi: 10.1590/s0365-05962013000100012.
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Acquired reactive perforating collagenosis: current status.获得性反应性穿孔性胶原病：现状。
J Dermatol. 2010 Jul;37(7):585-92. doi: 10.1111/j.1346-8138.2010.00918.x.
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Acquired reactive perforating collagenosis associated with diabetes mellitus: eight cases that meet Faver's criteria.与糖尿病相关的获得性反应性穿通性胶原病：8例符合法弗标准的病例。
Br J Dermatol. 1999 Mar;140(3):521-4. doi: 10.1046/j.1365-2133.1999.02722.x.
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Acquired reactive perforating collagenosis. Report of six cases and review of the literature.获得性反应性穿通性胶原病。6例报告及文献复习。
J Am Acad Dermatol. 1994 Apr;30(4):575-80. doi: 10.1016/s0190-9622(94)70065-6.
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The perforating disorders.穿孔性疾病。
J Am Acad Dermatol. 1984 Apr;10(4):561-81. doi: 10.1016/s0190-9622(84)80259-5.