White Ian, Tuohy Megan, Turner Michael, Lee Albert
Department of Neurological Surgery, Indiana University School of Medicine, Goodman Campbell Brain and Spine, Indianapolis, Indiana.
Neurosurgery. 2021 Jan 13;88(2):306-312. doi: 10.1093/neuros/nyaa417.
Shunting procedures have a high failure rate when used to treat pseudotumor cerebri (PTC) patients who have failed medical therapy. This failure is believed to be attributable to the collapsibility of the ventricular system when exposed to increased differential pressure gradients in the cerebral spinal fluid compartments caused by ventriculoperitoneal shunts (VPS).
To investigate whether prepontine/interpeduncular cistern shunting may be a reasonable alternative to VPS intervention in PTC patients with history of shunt failure. There have been no large series of cisternal-peritoneal shunt (CPS) patients in the PTC population.
A retrospective review of 49 patients with placement of CPS for PTC with 2 failed prior shunting procedures was performed. Shunt survivability was based on shunt patency and resolution of ophthalmologic symptoms and cranial nerve deficits. All patients were followed for a minimum of 3 yr with serial ophthalmologic and neurosurgical evaluations.
At 3 yr, 44 of the 49 (88.9%) patients had working CPS. Three patients in this group had infections requiring complete shunt removal. Excluding infections, 44 of 46 (95.5%) shunts were functional at 3 yr. There were 3 small, asymptomatic hemorrhages that did not increase patient length of stay, and there were no catastrophic hemorrhages or strokes. There were also no abdominal complications related to shunt placement.
CPS is a viable alternative to VPS in PTC patients who have failed traditional shunting methods to give these patients a persistent benefit of a working shunt. The procedure provides this solution with low operative and perioperative morbidity.
分流手术用于治疗药物治疗无效的假性脑瘤(PTC)患者时失败率很高。这种失败被认为是由于脑室腹腔分流术(VPS)导致脑脊液腔室间压差增加时脑室系统的可塌陷性所致。
探讨脑桥前/脚间池分流术是否可能是有分流失败史的PTC患者VPS干预的合理替代方案。PTC人群中尚无大量的脑池-腹腔分流术(CPS)患者系列报道。
对49例行CPS治疗PTC且先前有2次分流手术失败的患者进行回顾性研究。分流存活率基于分流通畅情况以及眼科症状和颅神经功能缺损的缓解情况。所有患者均接受了至少3年的系列眼科和神经外科评估。
3年时,49例患者中有44例(88.9%)的CPS仍在发挥作用。该组中有3例患者发生感染,需要完全移除分流装置。排除感染因素后,46例患者中有44例(95.5%)的分流装置在术后3年仍能正常工作。有3例小的无症状出血,未增加患者住院时间,也没有发生灾难性出血或中风。也没有与分流放置相关的腹部并发症。
对于传统分流方法失败的PTC患者,CPS是VPS的可行替代方案,可为这些患者提供持续有效的分流益处。该手术以较低的手术和围手术期发病率提供了这一解决方案。