National Institute of Hematology and Blood Transfusion, Hanoi, Vietnam.
Terumo BCT, Lakewood, Colorado, USA.
J Clin Apher. 2021 Feb;36(1):101-108. doi: 10.1002/jca.21847. Epub 2020 Oct 10.
Thrombocytosis is usually seen in myeloproliferative neoplasms (MPNs) and associated with thrombohemorrhagic complications. Therapeutic thrombocytapheresis using an automatic cell separator can help to achieve prompt platelet count reduction to decrease the rate of thrombotic events. In this study, we report a single center's experience in managing MPN patients with thrombocytapheresis prior to chemotherapy. Thrombocytapheresis procedures were performed in 185 MPN patients with thrombocytosis between January 2016 and June 2017. The median percentage reduction of platelets was 44.5% and the median percentage removal efficiency was 65.2% for 83 procedures where the waste bag was sampled. Procedures were generally well tolerated with few patients having mild adverse events (13 out of 185 patients).
血小板增多症通常见于骨髓增殖性肿瘤（MPN），并与血栓出血并发症相关。使用自动细胞分离机进行治疗性血小板清除术有助于迅速降低血小板计数，从而降低血栓事件的发生率。在这项研究中，我们报告了单中心在化疗前使用血小板清除术治疗 MPN 患者的经验。2016 年 1 月至 2017 年 6 月，对 185 例血小板增多的 MPN 患者进行了血小板清除术。在对 83 次使用废物袋取样的程序中，血小板的中位数降幅为 44.5%，中位数去除效率为 65.2%。这些程序通常耐受性良好，只有少数患者出现轻微的不良反应（185 例患者中有 13 例）。
