Inonu University, Turgut Ozal Medical Center, Department of Hematology, Malatya, Turkey.
Inonu University, Turgut Ozal Medical Center, Department of Hematology, Malatya, Turkey.
Transfus Clin Biol. 2023 Nov;30(4):421-425. doi: 10.1016/j.tracli.2023.08.001. Epub 2023 Aug 7.
Essential thrombocythemia is one of the chronic myeloproliferative neoplasms characterized by clonal proliferation of myeloid cells with variable morphological maturation and hematopoietic activity.It is characterized by excessive clonal platelet production with a tendency to thrombosis and bleeding. Thrombocytapheresıs is the removal of platelets by apheresis techniques. Thrombocytapheresıs is generally recommended in patients with essential thrombocythemia with acute, severe thrombotic or hemorrhagic events.
The study included 39 patients who were diagnosed with essential thrombocythemia, started cytoreductive and aspirin therapy, and underwent thrombocytapheresıs due to the development of acute severe thrombotic or hemorrhagic events, diagnosed in the adult hematology clinic of İnönü University Turgut Ozal Medical Center. Hemogram and biochemistry values of the patients were scanned retrospectively.
After thrombocytapheresıs, a statistically significant difference was found between the first and last measurements of hemoglobin, mean platelet volume, White blood cell, neutrophil, platelet, platelet distribution width, creatine, lactate dehydrogenase, fibronogen and calcium levels of the patients.
The use of thrombocytapheresıs in patients with essential thrombocytosis causes a rapid decrease in platelet values as well as an effect on hemogram and biochemistry parameters. Other hemogram and biochemistry parameters such as platelet value should be monitored in patients.
特发性血小板增多症是一种慢性骨髓增生性肿瘤，其特征是髓系细胞的克隆性增殖，具有不同程度的形态成熟和造血活性。它的特征是过度克隆性血小板生成，有血栓形成和出血的倾向。血小板清除术是通过分离技术去除血小板。血小板清除术通常推荐用于特发性血小板增多症患者，这些患者有急性、严重的血栓形成或出血事件。
该研究纳入了 39 名在因急性严重血栓形成或出血事件而在 İnönü 大学图古特·厄扎尔医疗中心成人血液科诊所诊断为特发性血小板增多症的患者，这些患者开始接受细胞减少和阿司匹林治疗，并接受了血小板清除术。回顾性扫描了患者的血常规和生化值。
血小板清除术后，患者的血红蛋白、平均血小板体积、白细胞、中性粒细胞、血小板、血小板分布宽度、肌酐、乳酸脱氢酶、纤维蛋白原和钙水平的第一次和最后一次测量值之间存在统计学显著差异。
在特发性血小板增多症患者中使用血小板清除术会导致血小板值迅速下降，并对血常规和生化参数产生影响。应监测其他血常规和生化参数，如血小板值。
