University of Miami Miller School of Medicine, Miami, FL, USA.
Harvard TH Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, USA.
Environ Res. 2021 Jan;192:110287. doi: 10.1016/j.envres.2020.110287. Epub 2020 Oct 8.
Poly- and perfluoroalkyl substances (PFAS) are persistent organic pollutants with pervasive exposure and suspected associations with metabolic abnormalities and adverse pregnancy outcomes. The goal of the present study was to examine the relationship between serum-PFAS concentrations measured in late pregnancy with relevant outcomes.
The study sample included 433 pregnant women enrolled in the Vanguard Pilot Study of the National Children's Study. Six PFAS were measured in primarily third trimester serum, as well as fasting insulin, total cholesterol, and triglycerides. The PFAS were examined in quartiles in relation to serum biomarkers, gestational age at birth and birth weight standardized for gestational age using multivariable-adjusted regression models.
Over 98% of the study population had detectable concentrations of four of the PFAS, and concentrations varied by race/ethnicity. Total cholesterol was positively associated with PFDA, PFNA, and PFOS, and triglycerides with PFDA, PFNA, PFOS, and PFOA, but PFAS were not associated with fasting insulin in adjusted models. Only PFNA was associated with an increased odds of birth at <37 weeks gestation. PFAS were generally not associated with birth weight, though PFHxS was associated with the first quartile of birth weight among males only.
This study of pregnant U.S. women supports the ubiquitous exposure to PFAS and positive associations between PFAS exposure with serum-lipid concentrations. PFAS were largely unassociated with gestational age at birth and birth weight, though PFNA was associated with preterm birth. The results support the vulnerability to PFAS exposure of pregnancy.
多氟和全氟烷基物质（PFAS）是具有持久性的有机污染物，具有广泛的暴露性，并被怀疑与代谢异常和不良妊娠结局有关。本研究的目的是研究妊娠晚期血清 PFAS 浓度与相关结局之间的关系。
本研究样本包括参加国家儿童研究先锋试点研究的 433 名孕妇。主要在第三孕期的血清中测量了 6 种 PFAS，以及空腹胰岛素、总胆固醇和甘油三酯。使用多变量调整回归模型，将 PFAS 按四分位数与血清生物标志物、出生时的胎龄和胎龄标准化的出生体重进行比较。
超过 98%的研究人群的四种 PFAS 可检测到浓度，且浓度因种族/族裔而异。总胆固醇与 PFDA、PFNA 和 PFOS 呈正相关，甘油三酯与 PFDA、PFNA、PFOS 和 PFOA 呈正相关，但在调整后的模型中，PFAS 与空腹胰岛素无关。只有 PFNA 与 <37 周的早产风险增加有关。PFAS 与出生体重一般无关联，不过仅在男性中，PFHxS 与出生体重的第一四分位数有关。
本研究对美国孕妇进行研究，支持 PFAS 普遍存在，PFAS 暴露与血清脂质浓度之间存在正相关。PFAS 与出生时的胎龄和出生体重的关联不大，尽管 PFNA 与早产有关。这些结果支持了妊娠对 PFAS 暴露的脆弱性。
