Breugnon E, Thollot H, Fraissenon A, Saunier F, Labetoulle R, Pillet S, Lucht F, Berthelot P, Botelho-Nevers E, Gagneux-Brunon A
Department of Hygiene and Infectious Diseases, University Hospital of Saint-Etienne, 42055 Saint-Etienne Cedex 2, France.
Department of Public health and biostatistics, University Hospital of Saint-Etienne, Saint-Etienne, France.
Infect Dis Now. 2021 Feb;51(1):71-76. doi: 10.1016/j.medmal.2020.10.001. Epub 2020 Oct 7.
Our aim is to compare the course of the disease between healthcare workers (HCWs) and non-HCWs suffering from covid-19 and eligible for outpatient management.
Single-center prospective cohort of outpatients with covid-19, diagnosed between the 10th March and the 2nd April, 2020 with a daily collection of symptoms by an on-line auto-questionnaire.
A total of 186 patients were included (median age, 41 years [interquartile range, 19-78 years]; 74.2% female), of whom 132 (71%) were HCWs. The median follow-up after symptom onset was 14 (min 4-max 24) days. HCWs were significantly younger than non-HCWs (median age 40.3 years vs. 47.2 years [P<0.005]), and 81.8% were women. Four patients (2.2%) were hospitalized including one HCW. The median time to recovery was 9 days after symptom onset (95% CI 8-11) in the global population and respectively 8 (95% CI 8-9) and 13 (95% CI 11-15) days in HCWs and in non-HCWs (P<0.005). After adjusting for age, co-morbidities, and gender, the instantaneous risk ratio for symptom absence in HCWs was 1.76 compared with non-HCWs (95% CI [1.16-2.67], P=0.037).
HCWs suffering from covid-19 had favorable outcomes and had a shorter time to recovery than non HCWs.
我们的目的是比较感染新冠病毒且适合门诊治疗的医护人员(HCWs)和非医护人员的疾病进程。
对2020年3月10日至4月2日期间确诊的新冠病毒门诊患者进行单中心前瞻性队列研究,通过在线自动问卷每日收集症状。
共纳入186例患者(中位年龄41岁[四分位间距,19 - 78岁];74.2%为女性),其中132例(71%)为医护人员。症状出现后的中位随访时间为14(最短4 - 最长24)天。医护人员明显比非医护人员年轻(中位年龄40.3岁对47.2岁[P<0.005]),且81.8%为女性。4例患者(2.2%)住院,其中包括1名医护人员。总体人群症状出现后恢复的中位时间为9天(95%置信区间8 - 11),医护人员和非医护人员分别为8天(95%置信区间8 - 9)和13天(95%置信区间11 - 15)(P<0.005)。在调整年龄、合并症和性别后,医护人员无症状的瞬时风险比与非医护人员相比为1.76(95%置信区间[1.16 - 2.67],P = 0.037)。
感染新冠病毒的医护人员预后良好,恢复时间比非医护人员短。