Department of Neurology, Tufts University School of Medicine, Lahey Hospital and Medical Center, 41 Mall Road, Burlington, MA 01805, USA.
Department of Neurology, Lahey Hospital and Medical Center, 41 Mall Road, Burlington, MA 01805, USA.
Neurol Clin. 2020 Nov;38(4):799-824. doi: 10.1016/j.ncl.2020.07.006.
Subacute toxic encephalopathies are challenging to identify due to their often insidious tempo of evolution, nonspecific manifestations, relative infrequency as individual entities, and frequent lack of specific diagnostic testing. Yet they are crucial to recognize-in aggregate, subacute toxic encephalopathies are a common problem that can lead to severe, irreversible harm if not diagnosed and treated efficiently. This article reviews the clinically relevant aspects of some of the more important subacute toxic encephalopathy syndromes caused by inorganic toxins, carbon monoxide, antibiotics, antineoplastic agents, and psychiatric medications.
亚急性中毒性脑病由于其演变常常具有隐匿性、表现非特异性、作为个体实体的相对罕见性以及缺乏特异性诊断检测的情况较为常见,因此难以识别。然而,认识到这些疾病非常重要——总的来说,亚急性中毒性脑病是一个常见问题,如果不能及时诊断和治疗,可能会导致严重的、不可逆转的伤害。本文综述了一些由无机毒素、一氧化碳、抗生素、抗肿瘤药物和精神药物引起的更重要的亚急性中毒性脑病综合征的临床相关方面。