Department of Health Management and Policy, University of Kentucky College of Public Health, 138 Leader Avenue, Lexington, KY 40506, USA.
Department of Neurology, University of Kentucky College of Medicine, 740 South Limestone Street, Lexington, KY 40536, USA.
Neurol Clin. 2020 Nov;38(4):965-981. doi: 10.1016/j.ncl.2020.08.002. Epub 2020 Sep 12.
Several different types of exposure have the potential to produce olfactory and gustatory deficits related to neurotoxicity. Although the literature contains relatively few studies of such chemoreceptive dysfunction in the context of toxic exposure, this review explores the strength of such published associations. Several studies collectively demonstrated moderately strong evidence for an association between manganese dust exposure and olfactory deficits. Evidence of associations between individual chemicals, therapeutics, and composites, such as World Trade Center debris, and olfactory and gustatory deficits remains limited or mixed. Further need for controlled studies for clinical management, exposure limits, and policy development is identified.
几种不同类型的暴露都有可能导致与神经毒性相关的嗅觉和味觉缺陷。尽管文献中关于有毒暴露背景下这种化学感受功能障碍的研究相对较少，但本综述探讨了这些已发表关联的强度。几项研究共同表明，接触锰尘与嗅觉缺陷之间存在中度强关联的证据。关于个别化学物质、疗法和混合物（如世界贸易中心废墟）与嗅觉和味觉缺陷之间的关联的证据仍然有限或相互矛盾。确定了进一步开展对照研究以进行临床管理、暴露限制和政策制定的需求。
