Shang Song'an, Chen Yu-Chen, Zhang Hongying, Dou Weiqiang, Qian Long, Yin Xindao, Wu Jingtao
Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Department of Radiology, Clinical Medical College, Yangzhou University, Yangzhou, China.
Front Neurosci. 2020 Sep 17;14:857. doi: 10.3389/fnins.2020.00857. eCollection 2020.
Cognitive impairment (CI) is a frequent non-motor symptom of Parkinson's disease (PD). Caudate and Apolipoprotein E (ApoE) are biomarkers linked to CI in PD. There is little known about whether ApoE affects caudate in mild CI of PD (PD-MCI). We investigated the possible interactive effect of ApoE genotypes on caudate functional connectivity (FC) in PD-MCI.
A total of 95 PD-MCI patients and 99 matched healthy controls underwent extensive neuropsychological assessment and magnetic resonance imaging. The two groups were separated into three subgroups according to their genotyping. Functional data were analyzed with FC analysis.
Decreased FC between the caudate and the bilateral inferior orbit frontal gyrus and bilateral middle occipital gyrus (MOG) was found between groups, along with poor performance in general, executive, episodic memory, language, and visual-spatial function. Decreased FC between the caudate and right MOG, right middle temporal gyrus, and right superior occipital gyrus was found as an interaction effect. The FC values of ε4 carriers with PD-MCI were much lower than the other carriers, and FC was positively correlated with the impairment of global and language function.
These results support the idea that altered FC between the bilateral caudate and posterior cortical regions was interactively influenced by ApoE genotype and PD-MCI status, and the ε4 subtype associated with underlying pathology of global cognitive decline and semantic fluency impairment in an interactive manner. Gene-based imaging approaches might strengthen the credibility in imaging genetic associations, which might provide new powerful insights into the neural mechanisms underlying PD-MCI.
认知障碍（CI）是帕金森病（PD）常见的非运动症状。尾状核和载脂蛋白E（ApoE）是与PD中的CI相关的生物标志物。关于ApoE是否影响PD轻度认知障碍（PD-MCI）中的尾状核，目前所知甚少。我们研究了ApoE基因型对PD-MCI中尾状核功能连接（FC）的可能交互作用。
共95例PD-MCI患者和99例匹配的健康对照者接受了广泛的神经心理学评估和磁共振成像。根据基因分型将两组分为三个亚组。功能数据采用FC分析进行分析。
发现两组之间尾状核与双侧眶额下回和双侧枕中回（MOG）之间的FC降低，同时在一般、执行、情景记忆、语言和视觉空间功能方面表现较差。发现尾状核与右侧MOG、右侧颞中回和右侧枕上回之间的FC降低是一种交互作用。PD-MCI的ε4携带者的FC值远低于其他携带者，且FC与整体和语言功能障碍呈正相关。
这些结果支持这样一种观点，即双侧尾状核与后皮质区域之间改变的FC受到ApoE基因型和PD-MCI状态的交互影响，并且ε4亚型以交互方式与整体认知下降和语义流畅性损害的潜在病理相关。基于基因的成像方法可能会加强成像遗传关联的可信度，这可能为PD-MCI潜在的神经机制提供新的有力见解。
