Pazzaglia U E, Dell'Orbo C, Wilkinson M J
Arch Orthop Trauma Surg (1978). 1987;106(4):209-19. doi: 10.1007/BF00450457.
An in vivo histological and ultrastructural study of the cellular reaction to particulate material currently used in orthopaedic surgery produced evidence that, on a strictly cellular level, the main damage is done by the smallest particles produced by hip prostheses, i.e. metal particles, irrespective of differences in their chemical composition. Particle size and release rate are the critical factors, although other mechanisms of cellular damage may be active once granulation tissue is formed.
一项关于目前骨科手术中使用的颗粒材料的细胞反应的体内组织学和超微结构研究表明，在严格的细胞水平上，主要损伤是由髋关节假体产生的最小颗粒造成的，即金属颗粒，无论其化学成分有何差异。颗粒大小和释放速率是关键因素，尽管一旦形成肉芽组织，其他细胞损伤机制可能也会起作用。
