Uchida S
Orthopedics. 1985 Oct;8(10):1276-80. doi: 10.3928/0147-7447-19851001-14.
The five kinds of prosthetic materials: powders of cobalt alloy, stainless steel, alumina ceramic, HDP plastic and bone cement, were injected to the knee joints of 16 rats for each material. Two controls were used, one with saline solution and the other untreated. Some of the rats were sacrificed at one week, being left untreated. Some of the rats were sacrificed at one, four, 12 and 25 weeks after injection. The knee joints of these rats were taken out for a histopathologic study. The main changes were fibrosis and granulation due to foreign bodies, but no remarkable change in the degree of tissue reactions was observed within each material group, nor did the length of period have any effect thereon. Comparing the degree of the above changes caused by each material in the tissue, ceramic powder showed the most significant change, followed by bone cement, HDP, stainless steel and cobalt alloy powder, in that order. No tumorous condition was observed.
将钴合金粉末、不锈钢粉末、氧化铝陶瓷粉末、高密度聚乙烯（HDP）塑料粉末和骨水泥这五种假体材料分别注入16只大鼠的膝关节。设置了两个对照组，一组注射生理盐水，另一组不做处理。部分大鼠在一周时处死，不予处理。部分大鼠在注射后1周、4周、12周和25周处死。取出这些大鼠的膝关节进行组织病理学研究。主要变化是异物引起的纤维化和肉芽组织形成，但各材料组内未观察到组织反应程度有显著变化，时间长短对此也无影响。比较各材料在组织中引起的上述变化程度，陶瓷粉末引起的变化最显著，其次依次是骨水泥、HDP、不锈钢和钴合金粉末。未观察到肿瘤情况。
