Pazzaglia U E
Clinica Ortopedica dell' Universitá di Pavia, IRCCS Policlinico San Matteo, Italy.
Arch Orthop Trauma Surg. 1990;109(1):49-52. doi: 10.1007/BF00441911.
Extensive localized bone lysis in the femur following implantation of a metal-on-metal total hip prosthesis was observed. Fragmentation of the cement occurred 10 years after implantation. Histologic and ultrastructural features of macrophages are consistent with the hypothesis that particles from the acrylic resin were the factors stimulating the macrophagic reaction. Both mechanical factors and changes of the physico-chemical properties of the cement may have an etiologic role.
观察到在植入金属对金属全髋关节假体后，股骨出现广泛的局限性骨质溶解。植入后10年发生了骨水泥碎裂。巨噬细胞的组织学和超微结构特征与以下假设一致，即丙烯酸树脂颗粒是刺激巨噬细胞反应的因素。机械因素和骨水泥物理化学性质的改变可能都具有病因学作用。
