Shao Zhiwei, Liu Lihong, Zheng Yanghao, Tu Sheng, Pan Yuanbo, Yan Sheng, Wei Qichun, Shao Anwen, Zhang Jianmin
Department of Hepatobiliary and Pancreatic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Oncol. 2020 Sep 11;10:538845. doi: 10.3389/fonc.2020.538845. eCollection 2020.
Meningioma is the most common tumor of the central nervous system, most of which is benign. Even after complete resection, a high rate of recurrence of meningioma is observed. From in-depth study of its pathogenesis, it has been found that a number of chromosomal variations and abnormal molecular signals are closely related to the occurrence and development of malignancy in meningioma, which may provide the theoretical basis and potential direction for accurate and targeted treatment. We have reviewed advances in chromosomal variations and molecular mechanisms involved in the progression of meningioma, and have highlighted the association with malignant biological behavior including cell proliferation, angiogenesis, increased invasiveness, and inhibition of apoptosis. In addition, the chemotherapy of meningioma is summarized and discussed.
脑膜瘤是中枢神经系统最常见的肿瘤，大多数为良性。即使在完全切除后，仍观察到脑膜瘤有较高的复发率。通过对其发病机制的深入研究，发现一些染色体变异和异常分子信号与脑膜瘤恶性肿瘤的发生和发展密切相关，这可能为精准靶向治疗提供理论依据和潜在方向。我们综述了脑膜瘤进展过程中染色体变异和分子机制的研究进展，并强调了其与包括细胞增殖、血管生成、侵袭性增加和凋亡抑制在内的恶性生物学行为的关联。此外，还对脑膜瘤的化疗进行了总结和讨论。
