Kaneko Shohei, Morino Junki, Minato Saori, Yanai Katsunori, Mutsuyoshi Yuko, Ishii Hiroki, Matsuyama Momoko, Kitano Taisuke, Shindo Mitsutoshi, Aomatsu Akinori, Miyazawa Haruhisa, Ueda Yuichiro, Ito Kiyonori, Hirai Keiji, Ookawara Susumu, Morishita Yoshiyuki
Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
Front Med (Lausanne). 2020 Sep 17;7:537586. doi: 10.3389/fmed.2020.537586. eCollection 2020.
Zinc deficiency is common and is associated with erythropoietin resistant anemia, dysgeusia, and hypogonadism in patients undergoing hemodialysis. However, the prevalence and clinical effects of zinc deficiency in patients undergoing peritoneal dialysis (PD) have not been determined. This was a retrospective, cross-sectional study. The prevalence of serum zinc deficiency and the clinical factors related to serum zinc concentration were determined in 49 patients undergoing PD [mean age 59.5 years (±14.8 years), 38/49 were men (78.6%), median PD period 24.0 months (12.5-45.0 months)]. A serum zinc concentration <60 μg/dL was defined as serum zinc deficiency, and a serum zinc concentration between 60 and 80 μg/dL as possible serum zinc deficiency. Serum zinc deficiency was present in 51% (25/49) of the patients, and possible serum zinc deficiency was present in 45% (22/49) of patients undergoing PD. Multivariate analysis showed that serum zinc concentration significantly correlated with serum ferritin concentration (β = 0.357, < 0.01). The prevalences of serum zinc deficiency and possible serum deficiency are high and serum zinc concentration correlates with serum ferritin concentration in patients undergoing PD.
锌缺乏很常见，并且与接受血液透析患者的促红细胞生成素抵抗性贫血、味觉障碍和性腺功能减退有关。然而，腹膜透析（PD）患者锌缺乏的患病率及其临床影响尚未确定。这是一项回顾性横断面研究。在49例接受PD的患者中（平均年龄59.5岁±14.8岁，49例中有38例为男性，占78.6%，PD中位时间24.0个月，范围12.5 - 45.0个月），确定了血清锌缺乏的患病率以及与血清锌浓度相关的临床因素。血清锌浓度<60μg/dL被定义为血清锌缺乏，血清锌浓度在60至80μg/dL之间被定义为可能的血清锌缺乏。51%（25/49）的患者存在血清锌缺乏，45%（22/49）接受PD的患者存在可能的血清锌缺乏。多变量分析显示，血清锌浓度与血清铁蛋白浓度显著相关（β = 0.357，P<0.01）。接受PD的患者血清锌缺乏和可能的血清缺乏患病率很高，且血清锌浓度与血清铁蛋白浓度相关。
