日本腹膜透析患者锌缺乏症的患病率：血液透析患者的对比研究。
Prevalence of Zinc Deficiency in Japanese Patients on Peritoneal Dialysis: Comparative Study in Patients on Hemodialysis.
机构信息
Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kami-cho, Itabashi-ku, Tokyo 173-8610, Japan.
出版信息
Nutrients. 2020 Mar 14;12(3):764. doi: 10.3390/nu12030764.
BACKGROUND
It is known that patients on hemodialysis (HD) are prone to developing zinc deficiency due to removal of zinc by HD, inadequate dietary intake, and reduced gastrointestinal zinc absorption. However, the prevalence of zinc deficiency in patients on peritoneal dialysis (PD) has not been well established.
METHODS
Serum zinc levels were compared between 47 patients on PD and 47 patients on HD matched for age, sex, and duration of dialysis. A serum zinc level < 60 μg/dL was defined as clinical zinc deficiency and a level of 60-80 μg/dL as subclinical zinc deficiency. The prevalence of zinc deficiency and associated clinical factors were determined in both groups.
RESULTS
Clinical zinc deficiency was found in 59.6% of the PD group and 70.2% of the HD group ( = 0.391). Subclinical zinc deficiency was found in 40.4% of the PD group and 29.8% of the HD group. Age, body mass index, and serum albumin level were identified as independent predictors of zinc deficiency in the PD group by multivariate analysis.
CONCLUSIONS
A higher prevalence of clinical and subclinical zinc deficiency was found in patients on PD. The rates were comparable between patients on PD and those on HD after adjustment for confounding factors.
背景
已知血液透析（HD）患者由于 HD 去除锌、饮食摄入不足和胃肠道锌吸收减少而易发生锌缺乏。然而，腹膜透析（PD）患者锌缺乏的患病率尚未得到很好的确定。
方法
比较了 47 名 PD 患者和 47 名匹配年龄、性别和透析时间的 HD 患者的血清锌水平。血清锌水平<60μg/dL 定义为临床锌缺乏，60-80μg/dL 定义为亚临床锌缺乏。确定了两组中锌缺乏症的患病率和相关临床因素。
结果
PD 组中临床锌缺乏的发生率为 59.6%，HD 组为 70.2%（=0.391）。PD 组亚临床锌缺乏的发生率为 40.4%，HD 组为 29.8%。多元分析确定年龄、体重指数和血清白蛋白水平是 PD 组锌缺乏的独立预测因素。
结论
PD 患者的临床和亚临床锌缺乏的患病率较高。在调整混杂因素后，PD 患者和 HD 患者之间的发生率相当。
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