College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, USA, TX.
Acta Pharmacol Sin. 2018 Jul;39(7):1120-1132. doi: 10.1038/aps.2018.25. Epub 2018 Jun 21.
Zinc is an essential nutrient for human health and has anti-oxidative stress and anti-inflammatory functions. The association between zinc deficiency and the development of cardiovascular diseases (CVDs) has been supported by numerous studies. Supplementing zinc can reduce the risk of atherosclerosis and protect against myocardial infarction and ischemia/reperfusion injury. In this review we summarize the evidence in the literature, to consolidate the current knowledge on the dysregulation of zinc homeostasis in CVDs, and to explore the significant roles of the zinc homeostasis-regulatory proteins in cardiac physiology and pathophysiology. Moreover, this review also deliberates on the potential diagnostic and prognostic implications of zinc/zinc homeostasis-associated molecules (ZIP, ZnT, and MTs) in CVDs.
锌是人体健康所必需的营养物质，具有抗氧化应激和抗炎功能。许多研究支持锌缺乏与心血管疾病（CVDs）的发展之间的关联。补充锌可以降低动脉粥样硬化的风险，并预防心肌梗死和缺血/再灌注损伤。在这篇综述中，我们总结了文献中的证据，以巩固目前关于 CVDs 中锌稳态失调的知识，并探讨锌稳态调节蛋白在心脏生理学和病理生理学中的重要作用。此外，本综述还讨论了 CVDs 中与锌/锌稳态相关的分子（ZIP、ZnT 和 MTs）的潜在诊断和预后意义。
