Department of Obstetrics & Gynecology, Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.
Department of Obstetrics & Gynecology, University of Michigan, Ann Arbor, MI, USA.
Int J Gynaecol Obstet. 2021 Apr;153(1):125-129. doi: 10.1002/ijgo.13419. Epub 2020 Nov 11.
To determine the efficacy and safety of intra-cardiac lidocaine administration to induce fetal demise before second-trimester medication abortion in a teaching hospital in Addis Ababa, Ethiopia.
We performed a retrospective chart review to collect selected sociodemographic and clinical information. All patients who received fetal intra-cardiac lidocaine between January 1, 2019 and April 30, 2019 were included in the study. Fetal demise was considered successful if achieved within 24 hours after fetal intra-cardiac lidocaine administration. We analyzed the data using SPSS version 20. We used frequency tables to describe the data and performed a multivariable analysis to determine associations between variables.
A total of 80 fetuses were given intra-cardiac lidocaine.The mean gestational age was 23 weeks (range 21 -27 weeks). Twenty-four hours after lidocaine administration 76 (95%) pregnancies showed negative fetal cardiac activity. Fetuses at gestational ages of 21-23 weeks were five times more likely to have negative cardiac activity compared with those with gestational ages between 24 and 28 weeks (P=0.001). Two women developed nausea, vomiting, and a metallic taste, but no serious adverse events were reported.
Intra-cardiac lidocaine is effective at inducing fetal demise before late second-trimester medication abortion with no associated serious adverse events or complications.
在埃塞俄比亚亚的斯亚贝巴的一家教学医院，确定在孕中期药物流产前，通过向胎儿心脏内注射利多卡因来终止妊娠的疗效和安全性。
我们进行了一项回顾性病历审查，以收集选定的社会人口学和临床信息。所有在 2019 年 1 月 1 日至 2019 年 4 月 30 日期间接受胎儿心脏内利多卡因注射的患者均纳入本研究。如果在胎儿心脏内利多卡因注射后 24 小时内胎儿死亡，则认为胎儿死亡成功。我们使用 SPSS 版本 20 分析数据。我们使用频率表来描述数据，并进行多变量分析以确定变量之间的关联。
共有 80 个胎儿接受了心脏内利多卡因注射。平均孕龄为 23 周（范围 21-27 周）。在利多卡因给药 24 小时后，76 例（95%）妊娠胎儿出现阴性胎心活动。与孕龄在 24 至 28 周之间的胎儿相比，孕龄在 21-23 周之间的胎儿发生阴性胎心活动的可能性高出五倍（P=0.001）。有 2 名女性出现恶心、呕吐和金属味，但未报告严重不良事件。
在孕中期药物流产前，通过向胎儿心脏内注射利多卡因来终止妊娠是有效的，且没有相关的严重不良事件或并发症。
