GKT School of Medical Education, King's College London, Guy's Campus, Great Maze Pond, London, UK.
Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, Guy's Campus, Great Maze Pond, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.
Reprod Sci. 2024 Feb;31(2):441-451. doi: 10.1007/s43032-023-01352-3. Epub 2023 Sep 25.
Feticide is the practice of inducing fetal demise before the termination of pregnancy. In England and Wales, it is recommended for terminations of pregnancy beyond 21+6 weeks of gestation. This project analyses the trends in feticide in singleton pregnancy in England and Wales between 2012 and 2020. This project was a retrospective study that analysed data extracted from the Health and Social Act 4 (HSA4) forms submitted to the Department of Health and Social Care (DHSC). The data extracted by the DHSC included the prevalence of feticide, methods of feticide and termination, statutory grounds, gestation, service provider, maternal age, ethnicity and obstetric history. In addition, data analysis was carried out to identify trends. Between 2012 and 2020, there were 9310 feticides in England and Wales, undertaken in 0.5% of all abortions. The prevalence of feticide fluctuated; however, there was an overall decrease from 1084 cases in 2012 to 1000 cases in 2020. Intracardiac injection of potassium chloride was the most frequent method of achieving feticide (67.2%). Just over half (55.8%) of feticides took place under Ground E of the Abortion Act 1967, with the main indication being congenital malformations of the nervous system. Two-fifths (40.2%) of feticides took place at 23 weeks, 22.8% at 22 weeks and 13.5% between 20 and 21 weeks. The remainder occurred at later gestations: 17.5% at 24-29 weeks and 5.9% beyond 29 weeks. During our study period, it was more common for feticides to be carried out as part of a medical termination than a surgical termination and 60.3% occurred in NHS hospitals. Women undergoing feticide were mostly aged 30-34 years (38.3%) and of White ethnicity (78.6%). Feticide is an essential component of comprehensive abortion care for women undergoing late second and third-trimester abortions. This study provides insight into how feticide is carried out in England and Wales and demonstrates the effect of the COVID-19 pandemic on reducing feticide prevalence. Future research should analyse in more detail the use of the different methods of feticide.
胎杀是指在妊娠终止前诱导胎儿死亡的行为。在英格兰和威尔士,它被推荐用于妊娠 21+6 周后终止妊娠。本项目分析了 2012 年至 2020 年间英格兰和威尔士单胎妊娠中胎杀的趋势。本项目是一项回顾性研究,分析了从提交给卫生部和社会关怀部 (DHSC) 的健康和社会法案 4 (HSA4) 表格中提取的数据。DHSC 提取的数据包括胎杀的流行率、胎杀和终止妊娠的方法、法定依据、妊娠、服务提供者、产妇年龄、种族和产科史。此外,还进行了数据分析以确定趋势。2012 年至 2020 年间,英格兰和威尔士共有 9310 例胎杀,占所有堕胎的 0.5%。胎杀的流行率波动不定;然而,从 2012 年的 1084 例到 2020 年的 1000 例,总体呈下降趋势。心内注射氯化钾是实现胎杀的最常见方法(67.2%)。超过一半(55.8%)的胎杀发生在 1967 年《堕胎法案》的 E 地上,主要指征是神经系统先天性畸形。五分之二(40.2%)的胎杀发生在 23 周,22.8%发生在 22 周,13.5%发生在 20-21 周之间。其余发生在妊娠后期:17.5%发生在 24-29 周,5.9%发生在 29 周以上。在我们的研究期间,胎杀作为医疗终止妊娠的一部分比手术终止妊娠更为常见,60.3%发生在 NHS 医院。进行胎杀的妇女大多年龄在 30-34 岁(38.3%),种族为白人(78.6%)。胎杀是对接受妊娠中晚期堕胎的妇女进行全面堕胎护理的重要组成部分。本研究深入了解了英格兰和威尔士胎杀的实施情况,并展示了 COVID-19 大流行对降低胎杀流行率的影响。未来的研究应更详细地分析不同胎杀方法的使用情况。