Zhao Youjin, Zhang Feifei, Zhang Wenjing, Chen Lizhou, Chen Ziqi, Lui Su, Gong Qiyong
Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China.
Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, China.
J Magn Reson Imaging. 2021 Mar;53(3):742-752. doi: 10.1002/jmri.27392. Epub 2020 Oct 12.
Major depressive disorder (MDD) has been increasingly conceptualized as a disconnection syndrome. However, most studies have only focused on functional connectivity (FC) alterations in gray matter (GM), and the functional alterations in white matter (WM) remain largely unknown in MDD.
To investigate WM functional alterations and the functional interaction between GM and WM networks in medication-naïve MDD.
Prospective.
Sixty-eight patients with MDD and 66 age- and sex-matched healthy controls (HCs).
FIELD STRENGTH/SEQUENCE: Resting state-functional MRI (fMRI) using a gradient-echo imaging sequence and T -weighted images were acquired at 3.0T.
Functional GM and WM networks, based on resting-state blood oxygenation level-dependent (BOLD) signals, were identified by the K-means clustering algorithm, and FC matrices were obtained for each subject.
Two-sample t-tests, Pearson chi-square test, and Pearson correlation analysis.
Both the GM and WM of the visual network (GM1 and WM11) showed reduced FC with the sensorimotor network (WM5 and GM8), lateral temporal network (GM5 and WM6), cingulo-opercular network (GM9), and dorsal attention network (GM7) in MDD patients compared to controls (P < 0.05, false discovery rate [FDR]-corrected). Reduced FC between the anterior cingulum network (WM3) and the lateral temporal network (GM5 and WM6) and temporal pole network (GM13) and between GM13 and the medial temporal network (GM4) and medial prefrontal-subcortical network (GM10) were also observed in MDD patients (P < 0.05, FDR-corrected). In addition, the WM BOLD signal in the sensorimotor network was negatively correlated with illness duration (r = -0.286, P = 0.018).
Disconnectivity between the GM and WM networks in the perception-motor system may be the foundation of extensively disrupted connections in MDD. Furthermore, the observed decoupling between subsystems of the default mode network may help explain previous findings of persistent negative rumination and theory of mind deficits in depression.
Stage 3.
重度抑郁症（MDD）越来越被视为一种连接障碍综合征。然而，大多数研究仅关注灰质（GM）中的功能连接（FC）改变，而在MDD中白质（WM）的功能改变仍 largely 未知。
研究未用药的MDD患者的WM功能改变以及GM和WM网络之间的功能相互作用。
前瞻性。
68例MDD患者和66例年龄及性别匹配的健康对照（HCs）。
场强/序列：在3.0T下使用梯度回波成像序列采集静息态功能磁共振成像（fMRI）和T加权图像。
基于静息态血氧水平依赖（BOLD）信号，通过K均值聚类算法识别功能GM和WM网络，并为每个受试者获得FC矩阵。
两样本t检验、Pearson卡方检验和Pearson相关分析。
与对照组相比，MDD患者视觉网络（GM1和WM11）的GM和WM与感觉运动网络（WM5和GM8）、外侧颞叶网络（GM5和WM6）、扣带 - 岛盖网络（GM9）和背侧注意网络（GM7）的FC均降低（P < 0.05，错误发现率[FDR]校正）。在MDD患者中还观察到前扣带网络（WM3）与外侧颞叶网络（GM5和WM6）以及颞极网络（GM13）之间以及GM13与内侧颞叶网络（GM4）和内侧前额叶 - 皮质下网络（GM10）之间的FC降低（P < 0.05，FDR校正）。此外，感觉运动网络中的WM BOLD信号与病程呈负相关（r = -0.286，P = 0.018）。
感知 - 运动系统中GM和WM网络之间的连接中断可能是MDD中广泛连接中断的基础。此外，默认模式网络子系统之间观察到的去耦可能有助于解释先前关于抑郁症中持续消极反刍和心理理论缺陷的发现。
3级。
3期。
