Department of Life Sciences, School of Sciences, European University Cyprus , Nicosia, Cyprus.
Cell Adh Migr. 2020 Dec;14(1):204-213. doi: 10.1080/19336918.2020.1829263.
Cell-extracellular matrix interactions, or focal adhesions (FA), are crucial for tissue homeostasis but are also implicated in cancer. Integrin-Linked Kinase (ILK) is an abundantly expressed FA protein involved in multiple signaling pathways. Here, we reviewed the current literature on the role of ILK in breast cancer (BC). Articles included in vitro and in vivo experiments as well as studies in human BC samples. ILK attenuation via silencing or pharmaceutical inhibition, leads to apoptosis or inhibition of epithelial-to-mesenchymal transition, and cell invasion whereas ILK overexpression suppresses anoikis and promotes tumor growth and metastasis. Finally, ILK is upregulated in BC tumors and its expression is associated with grade, and metastasis. Therefore, ILK should be evaluated as a potential anti-cancer pharmaceutical target.
细胞-细胞外基质相互作用，或焦点黏附（FA），对组织内稳态至关重要，但也与癌症有关。整合素连接激酶（ILK）是一种丰富表达的 FA 蛋白，参与多种信号通路。在这里，我们回顾了 ILK 在乳腺癌（BC）中的作用的现有文献。包括体内和体外实验以及人类 BC 样本的研究。通过沉默或药物抑制 ILK，可导致细胞凋亡或抑制上皮-间充质转化和细胞侵袭，而 ILK 过表达可抑制失巢凋亡并促进肿瘤生长和转移。最后，ILK 在 BC 肿瘤中上调，其表达与分级和转移相关。因此，ILK 应作为一种潜在的抗癌药物靶标进行评估。
