Horton Edward R, Humphries Jonathan D, James Jenny, Jones Matthew C, Askari Janet A, Humphries Martin J
Wellcome Trust Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK.
Wellcome Trust Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK
J Cell Sci. 2016 Nov 15;129(22):4159-4163. doi: 10.1242/jcs.192054. Epub 2016 Oct 31.
The adhesion nexus is the site at which integrin receptors bridge intracellular cytoskeletal and extracellular matrix networks. The connection between integrins and the cytoskeleton is mediated by a dynamic integrin adhesion complex (IAC), the components of which transduce chemical and mechanical signals to control a multitude of cellular functions. In this Cell Science at a Glance article and the accompanying poster, we integrate the consensus adhesome, a set of 60 proteins that have been most commonly identified in isolated IAC proteomes, with the literature-curated adhesome, a theoretical network that has been assembled through scholarly analysis of proteins that localise to IACs. The resulting IAC network, which comprises four broad signalling and actin-bridging axes, provides a platform for future studies of the regulation and function of the adhesion nexus in health and disease.
黏附连接点是整合素受体连接细胞内细胞骨架网络和细胞外基质网络的位点。整合素与细胞骨架之间的连接由动态整合素黏附复合体（IAC）介导，其组成成分可转导化学和机械信号以控制多种细胞功能。在这篇“细胞科学一览”文章及随附的海报中，我们将已在分离的IAC蛋白质组中最常鉴定出的一组60种蛋白质组成的共识黏附体，与通过对定位于IAC的蛋白质进行学术分析而构建的理论网络——文献整理黏附体进行整合。由此产生的IAC网络包含四个广泛的信号传导和肌动蛋白桥接轴，为未来研究黏附连接点在健康和疾病中的调节及功能提供了一个平台。
