不安腿综合征与加拿大老龄化纵向研究中的客观测量的动脉粥样硬化。
Restless Leg Syndrome and Objectively-Measured Atherosclerosis in the Canadian Longitudinal Study on Aging.
机构信息
Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada.
Center for Outcomes Research and Evaluation (CORE), Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
出版信息
Mov Disord. 2020 Dec;35(12):2314-2318. doi: 10.1002/mds.28326. Epub 2020 Oct 12.
BACKGROUND
Previous studies suggest associations between restless leg syndrome (RLS) and atherosclerosis, but these have primarily been based upon subjective atherosclerotic measures.
OBJECTIVE
We evaluated associations between RLS and an objective indicator of atherosclerosis, namely carotid intima-media thickness (cIMT).
METHODS
In this cross-sectional study among 30,097 Canadian Longitudinal Study on Aging (CLSA) participants, we used a four-item questionnaire to screen for probable-RLS. cIMT was measured at the bifurcation of the common carotid artery. Associations were tested with linear regression adjusting for age, sex, ferritin, pulmonary disease, smoking, alcohol, physical activity, anxiety, depression, and other sleep diagnoses.
RESULTS
Among 26,304 included participants, 2047 (7.8%) had probable-RLS. Mean cIMT was higher (0.755 ± 0.17 vs 0.736 ± 0.17, P < 0.001) in those with RLS, even after excluding those without prior atherosclerotic diseases (0.740 ± 0.17 vs 0.723 ± 0.16, P = 0.016).
CONCLUSION
RLS is associated with objective measures of atherosclerosis. © 2020 International Parkinson and Movement Disorder Society.
背景
先前的研究表明，不宁腿综合征（RLS）与动脉粥样硬化之间存在关联，但这些研究主要基于主观的动脉粥样硬化测量。
目的
我们评估了 RLS 与动脉粥样硬化的一个客观指标——颈动脉内膜中层厚度（cIMT）之间的关联。
方法
在这项 30097 名加拿大老龄化纵向研究（CLSA）参与者的横断面研究中，我们使用一个四项问卷来筛查可能的 RLS。在颈总动脉分叉处测量 cIMT。使用线性回归来测试与年龄、性别、铁蛋白、肺部疾病、吸烟、饮酒、身体活动、焦虑、抑郁和其他睡眠诊断相关的关联，并进行调整。
结果
在纳入的 26304 名参与者中，2047 名（7.8%）患有可能的 RLS。即使在排除无先前动脉粥样硬化疾病的患者后，RLS 患者的平均 cIMT 也更高（0.755±0.17 比 0.736±0.17，P<0.001）（0.740±0.17 比 0.723±0.16，P=0.016）。
结论
RLS 与动脉粥样硬化的客观测量指标相关。© 2020 国际帕金森病和运动障碍学会。
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