Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Utah School of Medicine, Salt Lake City, Utah.
Department of Obstetrics and Gynecology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York.
Clin Obstet Gynecol. 2020 Dec;63(4):720-734. doi: 10.1097/GRF.0000000000000578.
Perimenopause often represents a physiologically challenging phase in women's lives. The clinical presentation of the perimenopause includes infertility, irregular menstrual cycles, menorrhagia, and new onset of or worsening of mood disorders. Unlike menopause, which is characterized by low levels of estradiol and progesterone, the hallmark of perimenopause is highly variable levels of estradiol and progesterone with abrupt increases and decreases that are often described as a hormonal roller coaster. This chapter invites general gynecologists to understand the hormonal basis of the common complaints of perimenopause and offers information about the physiology of these issues and helpful treatment options.
围绝经期通常是女性生活中一个具有生理挑战性的阶段。围绝经期的临床表现包括不孕、月经周期不规律、月经过多，以及情绪障碍的新发病或恶化。与以雌二醇和孕酮水平低为特征的绝经不同，围绝经期的标志是雌二醇和孕酮水平高度变化，伴有突然增加和减少，通常被描述为荷尔蒙过山车。本章邀请普通妇科医生了解围绝经期常见症状的激素基础，并提供有关这些问题的生理学知识和有帮助的治疗选择。
