[小鼠造血系统对福氏志贺菌2A强毒株和无毒株给药的反应]
[Reaction of the hematopoietic system in mice to the administration of virulent and avirulent strains of Shigella flexneri 2A].
作者信息
Nikolaeva T N, Sanin A V, Belaia Iu A
出版信息
Nauchnye Doki Vyss Shkoly Biol Nauki. 1987(6):17-22.
The influence of live bacteria and antigenic preparations of virulent and avirulent stains of Shigella flexneri 2a on the endogenous splenic colony formation in murine hematopoietic cells has been studied. The different stimulating activity of live microbial cells of virulent and avirulent strains Shigella flexneri 2a and their antigenic preparations on the endogenous colony formation has been shown. The effect observed depends on the preparation doses and time of their administration before irradiation of the animals. The stimulating influence on the development of hemopoiesis endogenous foci may be conditioned by the action of heat-labile products of the live microbial cells and closely correlates with the virulence of strains studied.
研究了弗氏志贺菌2a强毒株和无毒株的活细菌及抗原制剂对小鼠造血细胞内源性脾集落形成的影响。结果显示，弗氏志贺菌2a强毒株和无毒株的活微生物细胞及其抗原制剂对内源性集落形成具有不同的刺激活性。观察到的效应取决于制剂剂量及其在动物照射前的给药时间。对造血内源性灶发展的刺激作用可能由活微生物细胞的热不稳定产物的作用所引起，并且与所研究菌株的毒力密切相关。
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