Borisov V A, Borisova E V, Solov'eva G A
Mikrobiol Z. 1994 May-Jun;56(3):55-9.
The influence of virulent and avirulent shigellae on delayed hypersensitivity in the case of infection by different methods has been examined. It was found that the stimulating effect of avirulent shigellae and suppressive effect of virulent shigellae were displayed after intranasal infection. Intraperitoneal and intravenous infection was accompanied by only immunosuppressive influence, which was displayed by the virulent bacteria. The discrimination of T-suppressors by low doses of cyclophosphamide did not abolish the suppressive effect of shigellae. At the same time immunosuppressive factor of spleen was produced equally after infection by different-virulence shigellae. A conclusion was drawn that T-suppressors and immunosuppressive spleen factor did not take part in the mechanism of shigellae immunosuppression.
研究了强毒和无毒志贺氏菌通过不同感染方法对迟发型超敏反应的影响。发现经鼻感染后，无毒志贺氏菌具有刺激作用，而强毒志贺氏菌具有抑制作用。腹腔注射和静脉注射感染仅伴有强毒细菌产生的免疫抑制作用。低剂量环磷酰胺对T抑制细胞的鉴别并未消除志贺氏菌的抑制作用。同时，不同毒力的志贺氏菌感染后，脾脏免疫抑制因子的产生量相同。得出的结论是，T抑制细胞和脾脏免疫抑制因子不参与志贺氏菌免疫抑制机制。
