Department of Neurosurgery, University Hospital of Strasbourg, 67100 Strasbourg, France.
Department of Radiotherapy, ICANS, 67100 Strasbourg, France.
Neurochirurgie. 2020 Dec;66(6):455-460. doi: 10.1016/j.neuchi.2020.06.135. Epub 2020 Oct 10.
The immunotherapy of cerebral glioblastoma has become a hot topic. Immune checkpoint blockade antibodies have progressively acquired a role in the management of malignant tumors. A multimodal approach using surgery, radiotherapy, chemotherapy in combination with immunotherapy represent a potent weapon against glioblastomas. In parallel, clinical applications of cryotherapy-freezing tumors based on repetition of rapid freeze-slow thaw cycle-for various cancers such as skin, lung, breast, esophagus, hepatic, kidney, prostate and bone tumors were developed. The future immunomodulatory approaches might be combined with brain tumors cryoablation to increase the cryoimmune response. The objective of this study was to analyze from the literature the relationship between cerebral cryosurgery and immunomodulation using PRISMA method. The animals' studies demonstrate the dendritic cells maturation and activation with the enhancement of antigen-presenting function after cryotherapy suggesting the potential usefulness of the association of cryotherapy and immunomodulator in the management of gliomas.
脑胶质瘤的免疫治疗已成为热点。免疫检查点阻断抗体在恶性肿瘤的治疗中逐渐发挥作用。手术、放疗、化疗联合免疫治疗的多模态方法是对抗脑胶质瘤的有力武器。与此同时，基于快速冷冻-缓慢解冻循环重复的无冷冻肿瘤冷冻疗法在各种癌症中的临床应用得到了发展，如皮肤、肺、乳腺、食管、肝、肾、前列腺和骨肿瘤。未来的免疫调节方法可能与脑肿瘤冷冻消融相结合，以增加冷冻免疫反应。本研究的目的是使用 PRISMA 方法从文献中分析脑冷冻手术与免疫调节之间的关系。动物研究表明，冷冻治疗后树突状细胞成熟和激活，并增强抗原呈递功能，提示冷冻治疗与免疫调节剂联合应用于胶质瘤治疗具有潜在的作用。
