Gobeaux D, Landais A, Bexon G, Cazaban J, Levron J C
Cah Anesthesiol. 1987 May-Jun;35(3):195-9.
This study was designed to investigate the effects of fentanyl associated with lidocaïne in a solution used to perform axillary brachial plexus nerve block. Adrenergic, sensory and motor nerve blocks have been studied separately and compared to a control group receiving lidocaine without fentanyl. For each type of fibre, the degree of block was measured on, 2, 3, 4, 5 and 10 minutes after injection and the result were studied by variance analysis. Axillary nerve blocks were performed in two different hospitals by two anesthesiologists. After giving informed consent, the patients were randomly allocated in two groups receiving 30 ml 1.5% lidocaine with 1/200,000 epinephrine, with or without fentanyl 100 mu. There were no statistical differences between the two groups as far as adrenergic nerve block was concerned, whereas sensory and motor nerve blocks were significantly more important as soon as five minutes after injection and lasted longer when fentanyl was added to the solution. This enhancement of intensity and duration of sensory and motor nerve blocks when fentanyl is added allows a reduction of the quantity of lidocaine required, and shortens the delay between injection and complete blockade.
本研究旨在探讨芬太尼与利多卡因混合溶液用于腋路臂丛神经阻滞的效果。分别研究了肾上腺素能神经、感觉神经和运动神经阻滞情况，并与接受不含芬太尼的利多卡因的对照组进行比较。对于每种类型的神经纤维，在注射后2、3、4、5和10分钟测量阻滞程度，并通过方差分析研究结果。由两名麻醉医生在两家不同医院进行腋路神经阻滞。在获得知情同意后，将患者随机分为两组，分别接受30毫升含1/200,000肾上腺素的1.5%利多卡因，其中一组添加100微克芬太尼，另一组不添加。就肾上腺素能神经阻滞而言，两组之间无统计学差异，而在注射后五分钟，感觉神经和运动神经阻滞明显更显著，并且当溶液中添加芬太尼时持续时间更长。添加芬太尼时感觉神经和运动神经阻滞强度和持续时间增强，使得所需利多卡因量减少，并缩短了注射与完全阻滞之间的延迟时间。
