Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Korean J Intern Med. 2021 Mar;36(2):447-455. doi: 10.3904/kjim.2019.348. Epub 2020 Oct 13.
BACKGROUND/AIMS: Recent evidence suggests an association between allergic sensitization and metabolic markers. However, this association has rarely been examined in the elderly. Retinol-binding protein-4 (RBP-4) is a recently identified adipokine that acts on the muscle and liver affecting insulin sensitivity. We evaluated the association between metabolic parameters and allergic sensitization in the elderly.
We analysed the database of the Korean Longitudinal Study on Health and Aging cohort study conducted during 2005 to 2006. Atopy was identified by inhalant allergen skin prick test. Metabolic conditions were assessed using anthropometric indices and serum biomarkers such as fasting glucose, lipid, adiponectin, and RBP-4.
Among the 854 elderly subjects, 17.2% had atopy. Plasma RBP-4 levels were significantly higher in the atopic elderly than nonatopic elderly (p = 0.003). When RBP-4 percentiles were categorized as under three groups, the prevalence of atopy and current rhinitis increased significantly with percentiles of RBP-4 levels (p = 0.019 and p = 0.007, respectively). Log RBP-4 was associated with atopy (odds ratio [OR], 4.10; p = 0.009) and current rhinitis (OR, 2.73; p = 0.014), but not with current asthma (OR, 1.17; p = 0.824). Higher RBP-4 level in atopic elderly was also observed in current rhinitis patients. Atopy, but not current rhinitis, showed significant relationships with log RBP-4 levels in multivariate analyses adjusted for other metabolic markers including body mass index.
RBP-4 positively associated with atopy in the general elderly population irrespective of other metabolic markers.
背景/目的：最近的证据表明，过敏致敏与代谢标志物之间存在关联。然而，这种关联在老年人中很少被研究。视黄醇结合蛋白-4（RBP-4）是一种最近发现的脂肪因子，作用于肌肉和肝脏，影响胰岛素敏感性。我们评估了代谢参数与老年人过敏致敏之间的关系。
我们分析了 2005 年至 2006 年进行的韩国纵向健康与老龄化研究队列研究的数据库。通过吸入性过敏原皮肤点刺试验确定过敏。使用人体测量学指标和血清生物标志物（如空腹血糖、脂质、脂联素和 RBP-4）评估代谢状况。
在 854 名老年人中，17.2%有过敏。与非过敏老年人相比，过敏老年人的血浆 RBP-4 水平明显更高（p = 0.003）。当 RBP-4 百分位分为三组时，过敏和当前鼻炎的患病率随着 RBP-4 水平的百分位显著增加（p = 0.019 和 p = 0.007，分别）。Log RBP-4 与过敏（比值比[OR]，4.10；p = 0.009）和当前鼻炎（OR，2.73；p = 0.014）相关，但与当前哮喘（OR，1.17；p = 0.824）无关。在当前患有鼻炎的老年人中，过敏的 RBP-4 水平也更高。在调整其他代谢标志物（包括体重指数）后，多变量分析显示，除其他代谢标志物外，过敏与 log RBP-4 水平呈显著相关。
RBP-4 与一般老年人群中的过敏呈正相关，而与其他代谢标志物无关。
