Hwang In Cheol, Lee Yong Joo, Ahn Hong Yup, Lee Sang Min
Department of Family Medicine, Gachon University Gil Medical Center, Incheon, Republic of Korea.
Department of Family Medicine, Seoul St. Mary's Hospital, The Catholic University College of Medicine, 222 Banpo-daero, Seocho-gu, Seoul, 137-701 Republic of Korea.
Allergy Asthma Clin Immunol. 2016 Jan 22;12:5. doi: 10.1186/s13223-015-0108-7. eCollection 2016.
Accumulating evidence indicates a strong correlation between allergic disease and cardiovascular risks. In spite of this, the data concerning the association between allergic rhinitis (AR) and cardiovascular risks is sparse and conflicting. This study aimed to investigate the association between AR prevalence and metabolic syndrome (MetS) in a large-scale, population-based survey, while considering the relevant risk factors.
A nationwide cross-sectional study was conducted based on data from 30,590 subjects aged 19 years and older, from the Korean National Health and Nutrition Survey 2007-2013. The odds ratios (ORs) and 95 % confidence intervals (CIs) of AR prevalence, based on MetS status and the presence of any MetS component, were calculated using multiple logistic regression analyses.
Regarding the characteristics of patients with AR and/or MetS, some variables had significant associations with disease in inverse directions for AR and MetS. Multivariate logistic analysis, with adjustments for demographic variables and health habits, indicated that AR prevalence was significantly lower in subjects with MetS (OR 0.84; 95 % CI 0.76-0.93), high blood pressure (OR 0.85; 95 % CI 0.77-0.94), or impaired fasting glucose (OR 0.81; 95 % CI 0.73-0.89). Furthermore, high blood pressure and impaired fasting glucose were significant predictors for reduced AR prevalence, independently of other MetS components.
In this population, AR was diagnosed less frequently in subjects with metabolic conditions. Well-designed prospective studies allowing for medical service utilization and collaborative basic research are warranted to elucidate the mechanism responsible for this inverse relationship.
越来越多的证据表明过敏性疾病与心血管风险之间存在密切关联。尽管如此，关于过敏性鼻炎（AR）与心血管风险之间关联的数据却很稀少且相互矛盾。本研究旨在通过一项大规模的基于人群的调查，在考虑相关风险因素的同时，探究AR患病率与代谢综合征（MetS）之间的关联。
基于2007 - 2013年韩国国民健康与营养调查中30590名19岁及以上受试者的数据，开展了一项全国性横断面研究。使用多因素逻辑回归分析计算基于MetS状态和任何MetS组分存在情况的AR患病率的比值比（OR）和95%置信区间（CI）。
关于AR和/或MetS患者的特征，一些变量在AR和MetS的患病情况上呈现出相反方向的显著关联。在对人口统计学变量和健康习惯进行调整的多因素逻辑分析中，结果表明，患有MetS（OR 0.84；95% CI 0.76 - 0.93）、高血压（OR 0.85；95% CI 0.77 - 0.94）或空腹血糖受损（OR 0.81；95% CI 0.73 - 0.89）的受试者中，AR患病率显著较低。此外，独立于其他MetS组分，高血压和空腹血糖受损是AR患病率降低的显著预测因素。
在该人群中，患有代谢性疾病的受试者AR诊断率较低。有必要开展精心设计的前瞻性研究，以考量医疗服务利用情况，并进行协作性基础研究，以阐明造成这种反向关系的机制。
