Department of Clinical Nursing, Medical University of Warsaw, Warsaw, Poland.
Phlebology. 2021 May;36(4):275-282. doi: 10.1177/0268355520961945. Epub 2020 Oct 12.
The aim of the study was to analyze bacterial flora in venous leg ulcers, empiric and targeted antibiotic therapy, and factors influencing healing time.
Data from 30 patients with venous leg ulcers were retrospectively analyzed. Collected data included: sociodemographic data, wounds information, number of comorbidities, results of the microbiological examination, and empiric and targeted antibiotic therapy. To compare the empiric and targeted treatment in terms of their compatibility, the group of patients was divided into the four subgroups: NEA (no empiric antibiotics), NA (no antibiotics), ETA+ (compatibility of empiric and targeted antibiotic), ETA- (no compatibility of empiric and targeted antibiotic).
The average ulcer healing time was 163.4 ± 97.1 (range 51.0 to 426.0) days and increased by 28 days with each additional bacterial strain in the ulcer (p = 0.041). Healing time did not differ between the four groups. and were the most frequent bacteria. Amoxicillinium/acidum clavulanicum was the most common empirical antibiotic and amoxicillinium/acidum clavulanicum, and levofloxacinum was the most common targeted antibiotic.
Venous leg ulcer healing time was prolonged with each subsequent bacterial strain in the ulcer, and it was independent from systemic antibiotic therapy.
本研究旨在分析静脉性下肢溃疡中的细菌菌群、经验性和靶向抗生素治疗以及影响愈合时间的因素。
回顾性分析了 30 例静脉性下肢溃疡患者的数据。收集的数据包括：社会人口统计学数据、伤口信息、合并症数量、微生物学检查结果以及经验性和靶向抗生素治疗。为了比较经验性和靶向治疗在兼容性方面的差异，将患者分为四个亚组：NEA（无经验性抗生素）、NA（无抗生素）、ETA+（经验性和靶向抗生素兼容）、ETA-（经验性和靶向抗生素不兼容）。
平均溃疡愈合时间为 163.4±97.1（范围 51.0 至 426.0）天，溃疡中每增加一种细菌，愈合时间增加 28 天（p=0.041）。四个亚组之间的愈合时间没有差异。和 是最常见的细菌。阿莫西林/克拉维酸是最常用的经验性抗生素，阿莫西林/克拉维酸和左氧氟沙星是最常用的靶向抗生素。
静脉性下肢溃疡的愈合时间随着溃疡中细菌种类的增加而延长，与全身抗生素治疗无关。
