Wellcome Critical Care Laboratory for Large Animals, Dryden Farm, University of Edinburgh, UK.
Division of Imaging and Technology, School of Medicine, University of Dundee, UK.
Lab Anim. 2021 Apr;55(2):177-180. doi: 10.1177/0023677220960509. Epub 2020 Oct 12.
Pigs are used to model humans in gastrointestinal (GI) studies because of their comparable size, physiology and behaviour: both are monogastric omnivores. A porcine surgical model for testing novel, tethered ultrasound capsule endoscopes (USCE) requires a clean, motile small intestine. Recommendations for human GI tract preparation before the mechanically similar process of video capsule endoscopy describe using oral purgatives, while high-carbohydrate drinks are recommended before colorectal surgery. Reports of the GI preparation of pigs exist but lack technical details, that is, administration, efficacy and side effects. This report details feeding a high-energy liquid diet to 11 female pigs undergoing surgery and USCE which was readily accepted and easily administered, and which produced a clean, motile small intestine and caused no detectable physiological/behavioural abnormalities.
猪因其大小、生理和行为与人类相似，常被用于胃肠道（GI）研究模型：两者都是单胃杂食动物。一种用于测试新型 tethered ultrasound capsule endoscopes（USCE）的猪外科模型需要一个干净、运动活跃的小肠。在进行机械上相似的视频胶囊内镜检查过程之前，推荐对人类胃肠道进行准备，描述使用口服泻药，而在结直肠手术前推荐高碳水化合物饮料。有关于猪胃肠道准备的报道，但缺乏技术细节，即给药、疗效和副作用。本报告详细介绍了对 11 头接受手术和 USCE 的雌性猪进行高能量液体饮食喂养，这种饮食容易接受和管理，并且可以产生干净、运动活跃的小肠，没有发现可检测到的生理/行为异常。
