Giroux L, Smeesters C, Corman J, Paquin F, Allaire G, St-Louis G, Daloze P
Can J Physiol Pharmacol. 1987 Jun;65(6):1125-31. doi: 10.1139/y87-177.
The classical triad of hemolytic uremic syndrome (microangiopathic hemolytic anemia, severe thrombopenia, and renal failure) developed de novo in three of our renal transplanted patients under cyclosporin A treatment. The predominant morphologic findings in the grafts consisted of glomerular and arteriolar thrombosis as well as arteriolonecrosis, all features of the syndrome. In one instance, ischemic bowel disease supervened after graft removal and was associated with persistent low grade microangiopathic process. De novo hemolytic uremic syndrome has been reported in patients treated with cyclosporin A following bone marrow or liver transplantation as well as in a few renal graft recipients. This peculiar form of cyclosporin A nephrotoxicity should not be confused with acute rejection of the renal transplant.
我们三名接受环孢素A治疗的肾移植患者出现了典型的溶血性尿毒症综合征三联征（微血管病性溶血性贫血、严重血小板减少症和肾衰竭）。移植肾的主要形态学表现为肾小球和小动脉血栓形成以及小动脉坏死，这些都是该综合征的特征。有一例患者在移植肾切除后并发缺血性肠病，并伴有持续性轻度微血管病过程。骨髓移植或肝移植后接受环孢素A治疗的患者以及少数肾移植受者中曾报道过新发溶血性尿毒症综合征。这种特殊形式的环孢素A肾毒性不应与肾移植的急性排斥反应相混淆。
