Jae Sae Young, Heffernan Kevin S, Kurl Sudhir, Kunutsor Setor K, Laukkanen Jari A
Department of Sport Science, University of Seoul, Seoul, Republic of Korea.
Department of Exercise Science, Syracuse University, Syracuse, USA.
Int J Stroke. 2021 Jul;16(5):551-555. doi: 10.1177/1747493020963762. Epub 2020 Oct 12.
Increased aortic stiffness, assessed as carotid-femoral pulse wave velocity (cfPWV), contributes to cerebrovascular damage and is predictive of cerebrovascular events.
We sought to examine the association between estimated pulse wave velocity (ePWV), a proxy of carotid-femoral pulse wave velocity, and stroke and its subtypes (ischemic and hemorrhagic) in a prospective cohort of 2666 men (aged mean 53.1, range 42-61 years) enrolled in the Kuopio Ischemic Heart Disease cohort study.
During a median 28-year follow-up, 471 incident stroke (397 ischemic and 94 hemorrhagic) events occurred. After adjusting for several established and emerging risk factors including age and pulse pressure, comparing the versus bottom quartiles of ePWV, there was an increased risk of stroke (hazard ratio [HR] 2.37, 95% Confidence Interval [CI]: 1.57-3.58), ischemic stroke (HR 2.23, 95% CI, 1.42-3.50), and hemorrhagic stroke (HR 3.57, 95% CI, 1.45-8.76).
These findings demonstrate that ePWV is independently associated with the risk of stroke in middle-aged men.
以颈股脉搏波速度（cfPWV）评估的主动脉僵硬度增加会导致脑血管损伤，并可预测脑血管事件。
我们试图在参加库奥皮奥缺血性心脏病队列研究的2666名男性（平均年龄53.1岁，范围42 - 61岁）的前瞻性队列中，研究估计脉搏波速度（ePWV，颈股脉搏波速度的替代指标）与中风及其亚型（缺血性和出血性）之间的关联。
在中位28年的随访期间，发生了471例新发中风事件（397例缺血性和94例出血性）。在调整了包括年龄和脉压在内的多个已确定和新出现的危险因素后，比较ePWV的最高四分位数与最低四分位数，中风风险增加（风险比[HR] 2.37，95%置信区间[CI]：1.57 - 3.58），缺血性中风（HR 2.23，95% CI，1.42 - 3.50），以及出血性中风（HR 3.57，95% CI，1.45 - 8.76）。
这些发现表明，ePWV与中年男性中风风险独立相关。
