Molecular Biology Division, Instituto Potosino de Investigacion Cientifica y Tecnologica A.C., San Luis Potosi, Mexico.
Curr Diabetes Rev. 2021;17(5):e121020186817. doi: 10.2174/1573399816999201012200537.
Numerous studies have shown a significant association between Type 2 Diabetes Mellitus (T2D) and Alzheimer's Disease (AD), two pathologies affecting millions of people worldwide. Chronic inflammation and oxidative stress are two conditions common to these diseases, also affecting the activity of the serpin Alpha-1-antichymotrypsin (ACT), but a possible common role for this serpin in T2D and AD remains unclear.
To explore the possible regulatory networks linking ACT to T2D and AD.
A bibliographic search was carried out in PubMed, Medline, Open-i, ScienceDirect, Scopus, and SpringerLink for data indicating or suggesting association among T2D, AD, and ACT. Searched terms like "alpha-1-antichymotrypsin", "type 2 diabetes", "Alzheimer's disease", "oxidative stress", "pro-inflammatory mediators" among others were used. Moreover, common therapeutic strategies between T2D and AD as well as the use of ACT as a therapeutic target for both diseases were included.
ACT has been linked with the development and maintenance of T2D and AD and studies suggest their participation through the activation of inflammatory pathways and oxidative stress, mechanisms also associated with both diseases. Likewise, evidences indicate that diverse therapeutic approaches are common to both diseases.
Inflammatory and oxidative stresses constitute a crossroad for T2D and AD, where ACT could play an important role. In-depth research on ACT involvement in these two dysfunctions could generate new therapeutic strategies for T2D and AD.
大量研究表明，2 型糖尿病（T2D）和阿尔茨海默病（AD）之间存在显著关联，这两种疾病影响着全球数以百万计的人。慢性炎症和氧化应激是这两种疾病共有的两种情况，也会影响丝氨酸蛋白酶抑制剂 Alpha-1-抗胰蛋白酶（ACT）的活性，但这种丝氨酸蛋白酶在 T2D 和 AD 中可能具有共同作用尚不清楚。
探索将 ACT 与 T2D 和 AD 联系起来的可能调节网络。
在 PubMed、Medline、Open-i、ScienceDirect、Scopus 和 SpringerLink 中进行文献检索，以获取表明或提示 T2D、AD 和 ACT 之间存在关联的数据。搜索的术语包括“alpha-1-antichymotrypsin”、“type 2 diabetes”、“Alzheimer's disease”、“oxidative stress”、“pro-inflammatory mediators”等。此外，还包括 T2D 和 AD 的常见治疗策略以及将 ACT 用作这两种疾病的治疗靶点。
ACT 与 T2D 和 AD 的发生和维持有关，研究表明它们通过炎症途径和氧化应激的激活参与其中，这些机制也与这两种疾病有关。同样，有证据表明，这两种疾病有多种共同的治疗方法。
炎症和氧化应激是 T2D 和 AD 的交汇点，ACT 可能在此过程中发挥重要作用。深入研究 ACT 在这两种功能障碍中的作用可能会为 T2D 和 AD 带来新的治疗策略。
