氧化钇纳米颗粒的抗氧化和抗炎特性：缓解糖尿病的新见解。
Antioxidant and Anti-inflammatory Properties of Yttrium Oxide Nanoparticles: New Insights into Alleviating Diabetes.
机构信息
School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia
出版信息
Curr Diabetes Rev. 2021;17(4):496-502. doi: 10.2174/1573399816999201012201111.
BACKGROUND
Diabetes mellitus is a metabolic disease that requires immediate attention. Oxidative stress that leads to the generation of reactive oxygen species is a contributing factor to the disease progression. Yttrium oxide nanoparticles (YO NPs) have a profound effect on alleviating oxidative damage.
METHODS
The literature related to YO NPs and oxidative stress has been thoroughly searched using PubMed and Scopus databases and relevant studies from inception until August 2020 were included in this scoping review.
RESULTS
YO NPs altered oxidative stress-related biochemical parameters in different disease models including diabetes.
CONCLUSION
Although YO NPs are a promising antidiabetic agent due to their antioxidant and anti- inflammatory properties, more studies are required to further elucidate the pharmacological and toxicological properties of these nanoparticles.
背景
糖尿病是一种需要立即关注的代谢性疾病。导致活性氧产生的氧化应激是疾病进展的一个因素。氧化钇纳米粒子（YO NPs）对缓解氧化损伤有显著影响。
方法
使用 PubMed 和 Scopus 数据库对与 YO NPs 和氧化应激相关的文献进行了全面检索，并纳入了从成立到 2020 年 8 月的相关研究，对这些研究进行了范围综述。
结果
YO NPs 改变了不同疾病模型（包括糖尿病）中与氧化应激相关的生化参数。
结论
尽管 YO NPs 具有抗氧化和抗炎特性，是一种很有前途的抗糖尿病药物，但仍需要更多的研究来进一步阐明这些纳米粒子的药理学和毒理学特性。
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