Suppr超能文献

标准化髋部骨折护理方案是否降低老年髋部骨折患者的死亡率?

Do standardized hip fracture care programs decrease mortality in geriatric hip fracture patients?

机构信息

Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA.

出版信息

Injury. 2021 Mar;52(3):541-547. doi: 10.1016/j.injury.2020.10.024. Epub 2020 Oct 6.

Abstract

There is mounting support for the implementation of a standardized hip fracture program (SHFP) for geriatric patients. However, the current evidence to assess geriatric hip fracture outcomes following treatment in a SHFP is limited to small, single-center, observational studies. Using a large, multinational dataset, this study aims to assess whether enrollment in a SHFP was associated with improved 30-day patient-important outcomes in geriatric hip fracture patients. The secondary aim was to evaluate if the SHFP treatment effect varies by baseline mortality risk. An observational cohort study was conducted using data from the National Surgical Quality Improvement Program (NSQIP) for the years of 2016 and 2017. The study included 17,395 geriatric hip fracture patients over the age of 65. Over half (54%) of patients were enrolled in a SHFP on admission to hospital. The primary outcome was 30-day mortality. Secondary outcomes included 30-day reoperation and readmission. Multivariable logistic regression was used to estimate treatment effects, adjusting for race, anesthesia technique, and baseline mortality risk. The heterogeneity of treatment effect was determined by stratifying patients into quartiles based on their baseline mortality risk. The overall 30-day mortality risk was 6.6%. Enrollment in a SHFP did not reduce the 30-day risk of mortality (risk difference (RD): -0.2; 95% CI: -0.7, 0.3; p = 0.48), reoperation (RD: -0.2%; 95% CI: -0.6, 0.3; p = 0.36) or readmission (RD: -0.4%; 95% CI: -0.1, 0.4%; p = 0.20) when analyzed as a single sample. However, there were greater differences in the SHFP treatment effects when stratified by their preoperative mortality risk. Specifically, a 2.0% (95% CI: 4.2, 0.0%; p = 0.06) reduction in mortality was observed in the patients in the highest risk quartile for mortality and a 1.7% (95% CI: -3.2, -0.2%; p = 0.02) reduction in the medium-high risk quartile. The NSQIP data suggest that SHFPs do not significantly improve the short-term outcomes for the average geriatric hip fracture patient. However, a SHFP may significantly reduce the risk of 30-day mortality in higher risk patients. Therefore, the efficiency of SHFPs could potentially be improved with targeted deployment to high risk geriatric hip fracture patients.

摘要

越来越多的人支持为老年患者实施标准化髋部骨折项目 (SHFP)。然而,目前评估接受 SHFP 治疗后老年髋部骨折患者结局的证据仅限于小型、单中心、观察性研究。本研究使用大型多国数据集,旨在评估老年髋部骨折患者入组 SHFP 是否与 30 天患者重要结局的改善相关。次要目的是评估 SHFP 治疗效果是否因基线死亡率风险而异。使用国家手术质量改进计划 (NSQIP) 的 2016 年和 2017 年的数据进行了一项观察性队列研究。该研究纳入了 17395 名年龄在 65 岁以上的老年髋部骨折患者。超过一半(54%)的患者在入院时就被纳入了 SHFP。主要结局是 30 天死亡率。次要结局包括 30 天再手术和再入院。多变量逻辑回归用于估计治疗效果,调整了种族、麻醉技术和基线死亡率风险。通过根据基线死亡率风险将患者分层到四分位数来确定治疗效果的异质性。总体 30 天死亡率风险为 6.6%。入组 SHFP 并未降低 30 天死亡率风险(风险差异 (RD):-0.2;95% CI:-0.7,0.3;p=0.48)、再手术风险 (RD:-0.2%;95% CI:-0.6,0.3;p=0.36) 或再入院风险 (RD:-0.4%;95% CI:-0.1,0.4%;p=0.20),当作为一个整体样本进行分析时。然而,当按术前死亡率风险分层时,SHFP 的治疗效果存在更大差异。具体来说,在死亡率风险最高的四分位数患者中,死亡率降低了 2.0%(95% CI:4.2,0.0%;p=0.06),而在中高危四分位数患者中,死亡率降低了 1.7%(95% CI:-3.2,-0.2%;p=0.02)。NSQIP 数据表明,SHFP 并不能显著改善普通老年髋部骨折患者的短期结局。然而,SHFP 可能显著降低高危患者 30 天死亡率的风险。因此,通过针对高危老年髋部骨折患者有针对性地部署,SHFP 的效率可能会提高。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验