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哪些髋部骨折患者有未接受抗骨质疏松治疗的风险?:一项美国外科医师学会国家外科质量改进计划(ACS NSQIP)分析。

Which patients are at risk for not receiving anti-osteoporosis treatment following hip fracture?: An ACS NSQIP analysis.

作者信息

Gordon Adam M, Malik Azeem Tariq, Khan Safdar N

机构信息

Department of Orthopaedics, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

出版信息

J Clin Orthop Trauma. 2021 Mar 20;17:169-175. doi: 10.1016/j.jcot.2021.03.009. eCollection 2021 Jun.

Abstract

BACKGROUND

Screening and management of osteoporosis is often only considered by providers when patients present with multiple fragility fractures. The objective was to determine which patients are at risk for not receiving anti-osteoporotic medication and screening immediately following open reduction internal fixation (ORIF) for hip fracture.

METHODS

The 2018 American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) Targeted Hip Fracture Database was queried to identify patients ≥ 50 years old who underwent ORIF of femoral neck, intertrochanteric hip, and subtrochanteric hip fractures. Patients with concurrent polytrauma, malignancy, and other fragility fractures were excluded. Patients taking osteoporotic medications immediately prior to hospitalization were excluded to prevent an overlap in the screening and/or antiresorptive medication initiation rates. Multi-variate logistic regression was used to assess for factors associated with not receiving anti-osteoporotic medication immediately postoperatively.

RESULTS

A total of 6179 patients were identified of whom 3304 (53.5%) were treated at a facility with a documented standardized hip fracture care program. Only 28.5% (N = 1766) patients received anti-osteoporosis medication immediately following ORIF. Independent factors associated with increased odds of not initiating bone protective medication were those without a standardized hip fracture care program (odds ratio [OR] 1.80 [1.58-2.06], P < 0.001), length of stay ≤ 5 days (odds ratio [OR] 1.47 [1.28-1.69], P < 0.001), patients waiting > 1 day until operation (odds ratio [OR] 1.35 [1.13-1.60], P = 0.001), patients requiring a mobility aid preoperatively (odds ratio [OR] 1.29 [1.13-1.47], P < 0.001), and patients who could not weight bear as tolerated (WBAT) on postoperative day 1 (POD 1) (odds ratio [OR] 1.25 [1.06-1.47], P = 0.008).

CONCLUSION

Patients starting anti-osteoporotic medication immediately following a hip fracture in the United States remains low (28.5%). Standardized hip fracture care programs have the greatest impact with regards to initiating anti-osteoporotic medication following hip fracture.

摘要

背景

骨质疏松症的筛查与管理通常只有在患者出现多处脆性骨折时,医疗服务提供者才会考虑。目的是确定哪些患者在接受髋部骨折切开复位内固定术(ORIF)后有未接受抗骨质疏松药物治疗及筛查的风险。

方法

查询2018年美国外科医师学会国家外科质量改进计划(ACS-NSQIP)的针对性髋部骨折数据库,以识别年龄≥50岁、接受股骨颈、转子间髋部和转子下髋部骨折ORIF的患者。排除合并多发伤、恶性肿瘤及其他脆性骨折的患者。排除住院前立即服用骨质疏松药物的患者,以避免筛查和/或抗吸收药物起始率出现重叠。采用多因素逻辑回归分析评估术后未立即接受抗骨质疏松药物治疗的相关因素。

结果

共识别出6179例患者,其中3304例(53.5%)在有记录的标准化髋部骨折护理计划的机构接受治疗。只有28.5%(N = 1766)的患者在ORIF后立即接受了抗骨质疏松药物治疗。与未开始使用骨保护药物几率增加相关的独立因素包括:没有标准化髋部骨折护理计划(比值比[OR] 1.80 [1.58 - 2.06],P < 0.001)、住院时间≤5天(比值比[OR] 1.47 [1.28 - 1.69],P < 0.001)、等待手术>1天的患者(比值比[OR] 1.35 [1.13 - 1.60],P = 0.001)、术前需要行动辅助器具的患者(比值比[OR] 1.29 [1.13 - 1.47],P < 0.001)以及术后第1天(POD 1)无法耐受负重(WBAT)的患者(比值比[OR] 1.25 [1.06 - 1.47],P = 0.008)。

结论

在美国,髋部骨折后立即开始抗骨质疏松药物治疗的患者比例仍然较低(28.5%)。标准化髋部骨折护理计划对髋部骨折后开始抗骨质疏松药物治疗的影响最大。

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