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泊洛妥珠单抗-维泊妥珠单抗联合苯达莫司汀和利妥昔单抗治疗弥漫性大B细胞淋巴瘤引起的急性胰腺炎

Acute Pancreatitis Induced by Polatuzumab-Vedotin-Piiq in Combination With Bendamustine and Rituximab for Diffuse Large B-Cell Lymphoma.

作者信息

Anderson Kara, Shehata Mena, Singh Davinder, Al-Ourani Mohammed

机构信息

Internal Medicine, Marshall University Joan C. Edwards School of Medicine, Huntington, USA.

Pulmonary and Critical Care, Marshall University Joan C. Edwards School of Medicine, Huntington, USA.

出版信息

Cureus. 2020 Sep 7;12(9):e10299. doi: 10.7759/cureus.10299.

DOI:10.7759/cureus.10299
PMID:33047089
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7540405/
Abstract

While alcohol and gallstones have been considered the most common causes of pancreatitis, we investigate two uncommon etiologies such as drug-induced and viral-induced. Pancreatitis, an inflammatory process, can lead to many complicated outcomes such as acute respiratory failure, sepsis, and death. Examining drug-induced pancreatitis poses a large challenge for physicians as majority of the data is extrapolated from case reports. This is made even more difficult for patients who are on large chemotherapeutic regimens which include multitude of drugs and various side effects. Besides patient medication regimens, other etiologies of pancreatitis must be ruled out such as viruses. We examine a case of a 48-year-old female undergoing treatment for diffuse large B-cell lymphoma with various chemotherapeutic agents and positive cultures for varicella zoster virus (VZV) presenting with diffuse epigastric abdominal pain.

摘要

虽然酒精和胆结石一直被认为是胰腺炎最常见的病因,但我们研究了两种不常见的病因,如药物性和病毒性。胰腺炎是一种炎症过程,可导致许多复杂的后果,如急性呼吸衰竭、败血症和死亡。对于医生来说,检查药物性胰腺炎是一项巨大的挑战,因为大多数数据是从病例报告中推断出来的。对于正在接受大型化疗方案(包括多种药物和各种副作用)的患者来说,这就更加困难了。除了患者的用药方案外,还必须排除胰腺炎的其他病因,如病毒。我们检查了一例48岁女性,她正在接受各种化疗药物治疗弥漫性大B细胞淋巴瘤,水痘带状疱疹病毒(VZV)培养呈阳性,表现为弥漫性上腹部腹痛。

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Acute Pancreatitis Induced by Polatuzumab-Vedotin-Piiq in Combination With Bendamustine and Rituximab for Diffuse Large B-Cell Lymphoma.泊洛妥珠单抗-维泊妥珠单抗联合苯达莫司汀和利妥昔单抗治疗弥漫性大B细胞淋巴瘤引起的急性胰腺炎
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本文引用的文献

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Acute Pancreatitis Due to Disseminated Varicella Zoster Infection in an Individual with Newly Diagnosed Human Immunodeficiency Virus.新诊断为人类免疫缺陷病毒感染个体中由播散性水痘带状疱疹感染引起的急性胰腺炎
Cureus. 2020 Feb 18;12(2):e7027. doi: 10.7759/cureus.7027.
2
Polatuzumab vedotin in combination with immunochemotherapy in patients with previously untreated diffuse large B-cell lymphoma: an open-label, non-randomised, phase 1b-2 study.泊洛妥珠单抗联合免疫化疗治疗未经治疗的弥漫性大 B 细胞淋巴瘤患者的开放性、非随机、1b-2 期研究。
Lancet Oncol. 2019 Jul;20(7):998-1010. doi: 10.1016/S1470-2045(19)30091-9. Epub 2019 May 14.
3
Acute pancreatitis in immunocompromised patients: beware of varicella zoster virus primo-infection.
免疫功能低下患者的急性胰腺炎:谨防水痘带状疱疹病毒原发性感染。
Clin Case Rep. 2017 Jun 22;5(8):1261-1263. doi: 10.1002/ccr3.1053. eCollection 2017 Aug.
4
Medication as a Cause of Acute Pancreatitis.药物作为急性胰腺炎的病因
Am J Case Rep. 2017 Jul 28;18:839-841. doi: 10.12659/ajcr.903327.
5
Elevated serum triglycerides are independently associated with persistent organ failure in acute pancreatitis.血清甘油三酯升高与急性胰腺炎患者持续器官功能衰竭独立相关。
Am J Gastroenterol. 2015 Oct;110(10):1497-503. doi: 10.1038/ajg.2015.261. Epub 2015 Sep 1.
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Infections associated with bendamustine containing regimens in hematological patients: a retrospective multi-center study.血液学患者中与含苯达莫司汀方案相关的感染:一项回顾性多中心研究。
Leuk Lymphoma. 2016;57(1):63-9. doi: 10.3109/10428194.2015.1046862. Epub 2015 May 25.
7
Safety and activity of the anti-CD79B antibody-drug conjugate polatuzumab vedotin in relapsed or refractory B-cell non-Hodgkin lymphoma and chronic lymphocytic leukaemia: a phase 1 study.抗 CD79B 抗体药物偶联物 polatuzumab vedotin 在复发或难治性 B 细胞非霍奇金淋巴瘤和慢性淋巴细胞白血病中的安全性和活性:一项 1 期研究。
Lancet Oncol. 2015 Jun;16(6):704-15. doi: 10.1016/S1470-2045(15)70128-2. Epub 2015 Apr 27.
8
A phase 1/1b study of rituximab, bendamustine, and ibrutinib in patients with untreated and relapsed/refractory non-Hodgkin lymphoma.一项利妥昔单抗、苯达莫司汀和伊布替尼治疗未经治疗和复发/难治性非霍奇金淋巴瘤患者的 1 期/1b 期研究。
Blood. 2015 Jan 8;125(2):242-8. doi: 10.1182/blood-2014-08-597914. Epub 2014 Oct 29.
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Bendamustine as salvage treatment for patients with relapsed or refractory mantle cell lymphoma patients: a retrospective study of the Spanish experience.苯达莫司汀作为挽救治疗方案用于复发/难治性套细胞淋巴瘤患者:一项西班牙经验的回顾性研究。
Ann Hematol. 2014 Sep;93(9):1551-8. doi: 10.1007/s00277-014-2077-1. Epub 2014 Apr 30.
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Clinical review: Serious adverse events associated with the use of rituximab - a critical care perspective.临床综述:使用利妥昔单抗相关的严重不良事件——重症监护视角
Crit Care. 2012 Aug 31;16(4):231. doi: 10.1186/cc11304.