Shen Haiwei, Liu Tao, Cheng Didi, Yi Xiao, Wang Ze, Liu Lei, Song Dingguo, Ling Fei, Zhong Weihui
Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China.
J Org Chem. 2020 Nov 6;85(21):13735-13746. doi: 10.1021/acs.joc.0c01879. Epub 2020 Oct 13.
A dehydrogenative [3 + 2] annulation reaction of aniline derivatives and alkenes has been developed via the ruthenium-electron catalytic systems for the synthesis of versatile indolines. Electricity is used as a sustainable oxidant to regenerate the active Ru(II) catalyst and promote H evolution. This protocol is ecofriendly and easy to handle as it uses a simple undivided cell in mild conditions without the employment of metal oxidants.
通过钌电子催化体系，开发了一种苯胺衍生物与烯烃的脱氢[3 + 2]环化反应，用于合成多功能吲哚啉。电被用作可持续氧化剂，以再生活性Ru(II)催化剂并促进氢气释放。该方法环保且易于操作，因为它在温和条件下使用简单的无隔膜电池，无需使用金属氧化剂。
