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电化学后期功能化

Electrochemical Late-Stage Functionalization.

作者信息

Wang Yulei, Dana Suman, Long Hao, Xu Yang, Li Yanjun, Kaplaneris Nikolaos, Ackermann Lutz

机构信息

Institut für Organische und Biomolekulare Chemie and Wöhler Research Institute for Sustainable Chemistry (WISCh), Georg-August-Universität, Göttingen 37077, Germany.

出版信息

Chem Rev. 2023 Oct 11;123(19):11269-11335. doi: 10.1021/acs.chemrev.3c00158. Epub 2023 Sep 26.

DOI:10.1021/acs.chemrev.3c00158
PMID:37751573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10571048/
Abstract

Late-stage functionalization (LSF) constitutes a powerful strategy for the assembly or diversification of novel molecular entities with improved physicochemical or biological activities. LSF can thus greatly accelerate the development of medicinally relevant compounds, crop protecting agents, and functional materials. Electrochemical molecular synthesis has emerged as an environmentally friendly platform for the transformation of organic compounds. Over the past decade, electrochemical late-stage functionalization (eLSF) has gained major momentum, which is summarized herein up to February 2023.

摘要

后期功能化（LSF）是一种用于组装或多样化具有改善的物理化学或生物活性的新型分子实体的强大策略。因此，LSF可以极大地加速与医学相关的化合物、作物保护剂和功能材料的开发。电化学分子合成已成为有机化合物转化的一个环境友好型平台。在过去十年中，电化学后期功能化（eLSF）已获得重大发展，本文总结了截至2023年2月的相关情况。

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