• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于膀胱癌免疫基因组图谱分析的预后基因特征鉴定

Identification of a prognostic gene signature based on an immunogenomic landscape analysis of bladder cancer.

作者信息

Luo Yongwen, Chen Liang, Zhou Qiang, Xiong Yaoyi, Wang Gang, Liu Xuefeng, Xiao Yu, Ju Lingao, Wang Xinghuan

机构信息

Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, China.

出版信息

J Cell Mol Med. 2020 Nov;24(22):13370-13382. doi: 10.1111/jcmm.15960. Epub 2020 Oct 13.

DOI:10.1111/jcmm.15960
PMID:33048468
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7701570/
Abstract

Cancer immune plays a critical role in cancer progression. Tumour immunology and immunotherapy are one of the exciting areas in bladder cancer research. In this study, we aimed to develop an immune-related gene signature to improve the prognostic prediction of bladder cancer. Firstly, we identified 392 differentially expressed immune-related genes (IRGs) based on TCGA and ImmPort databases. Functional enrichment analysis revealed that these genes were enriched in inflammatory and immune-related pathways, including in 'regulation of signaling receptor activity', 'cytokine-cytokine receptor interaction' and 'GPCR ligand binding'. Then, we separated all samples in TCGA data set into the training cohort and the testing cohort in a ratio of 3:1 randomly. Data set GSE13507 was set as the validation cohort. We constructed a prognostic six-IRG signature with LASSO Cox regression in the training cohort, including AHNAK, OAS1, APOBEC3H, SCG2, CTSE and KIR2DS4. Six IRGs reflected the microenvironment of bladder cancer, especially immune cell infiltration. The prognostic value of six-IRG signature was further validated in the testing cohort and the validation cohort. The results of multivariable Cox regression and subgroup analysis revealed that six-IRG signature was a clinically independent prognostic factor for bladder cancer patients. Further, we constructed a nomogram based on six-IRG signature and other clinicopathological risk factors, and it performed well in predict patients' survival. Finally, we found six-IRG signature showed significant difference in different molecular subtypes of bladder cancer. In conclusions, our research provided a novel immune-related gene signature to estimate prognosis for patients' survival with bladder cancer.

摘要

癌症免疫在癌症进展中起着关键作用。肿瘤免疫学和免疫疗法是膀胱癌研究中令人兴奋的领域之一。在本研究中，我们旨在开发一种免疫相关基因特征，以改善膀胱癌的预后预测。首先，我们基于TCGA和ImmPort数据库鉴定了392个差异表达的免疫相关基因（IRG）。功能富集分析表明，这些基因富集于炎症和免疫相关途径，包括“信号受体活性调节”、“细胞因子-细胞因子受体相互作用”和“GPCR配体结合”。然后，我们将TCGA数据集中的所有样本以3:1的比例随机分为训练队列和测试队列。数据集GSE13507被设为验证队列。我们在训练队列中用LASSO Cox回归构建了一个预后六基因IRG特征，包括AHNAK、OAS1、APOBEC3H、SCG2、CTSE和KIR2DS4。六个IRG反映了膀胱癌的微环境，尤其是免疫细胞浸润。六基因IRG特征的预后价值在测试队列和验证队列中得到进一步验证。多变量Cox回归和亚组分析结果表明，六基因IRG特征是膀胱癌患者的临床独立预后因素。此外，我们基于六基因IRG特征和其他临床病理风险因素构建了一个列线图，它在预测患者生存方面表现良好。最后，我们发现六基因IRG特征在膀胱癌的不同分子亚型中存在显著差异。总之，我们的研究提供了一种新的免疫相关基因特征，用于估计膀胱癌患者的生存预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04da/7701570/9cc590a1e957/JCMM-24-13370-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04da/7701570/03d740ba8c25/JCMM-24-13370-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04da/7701570/b96729ef1bb1/JCMM-24-13370-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04da/7701570/a458ef19c2a6/JCMM-24-13370-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04da/7701570/38aa748ee9ff/JCMM-24-13370-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04da/7701570/644c25621f47/JCMM-24-13370-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04da/7701570/859e595c0957/JCMM-24-13370-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04da/7701570/ab441cd5b252/JCMM-24-13370-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04da/7701570/9cc590a1e957/JCMM-24-13370-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04da/7701570/03d740ba8c25/JCMM-24-13370-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04da/7701570/b96729ef1bb1/JCMM-24-13370-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04da/7701570/a458ef19c2a6/JCMM-24-13370-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04da/7701570/38aa748ee9ff/JCMM-24-13370-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04da/7701570/644c25621f47/JCMM-24-13370-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04da/7701570/859e595c0957/JCMM-24-13370-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04da/7701570/ab441cd5b252/JCMM-24-13370-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04da/7701570/9cc590a1e957/JCMM-24-13370-g008.jpg

相似文献

1
Identification of a prognostic gene signature based on an immunogenomic landscape analysis of bladder cancer.基于膀胱癌免疫基因组图谱分析的预后基因特征鉴定
J Cell Mol Med. 2020 Nov;24(22):13370-13382. doi: 10.1111/jcmm.15960. Epub 2020 Oct 13.
2
Development of a prognostic index and screening of prognosis related genes based on an immunogenomic landscape analysis of bladder cancer.基于膀胱癌免疫基因组图谱分析的预后指数开发和预后相关基因筛选。
Aging (Albany NY). 2021 Apr 22;13(8):12099-12112. doi: 10.18632/aging.202917.
3
A novel risk score based on a combined signature of 10 immune system genes to predict bladder cancer prognosis.一种基于10个免疫系统基因联合特征的新型风险评分，用于预测膀胱癌预后。
Int Immunopharmacol. 2020 Oct;87:106851. doi: 10.1016/j.intimp.2020.106851. Epub 2020 Aug 5.
4
Identification of immune-related genes that predict prognosis and risk of bladder cancer: bioinformatics analysis of TCGA database.基于 TCGA 数据库的生物信息学分析鉴定预测膀胱癌预后和风险的免疫相关基因
Aging (Albany NY). 2021 Jul 30;13(15):19352-19374. doi: 10.18632/aging.203333.
5
Identification and Validation of an Individualized Prognostic Signature of Bladder Cancer Based on Seven Immune Related Genes.基于七个免疫相关基因的膀胱癌个体化预后特征的鉴定与验证
Front Genet. 2020 Feb 5;11:12. doi: 10.3389/fgene.2020.00012. eCollection 2020.
6
Development and validation of an immune gene-set based prognostic signature for soft tissue sarcoma.基于免疫基因集的软组织肉瘤预后特征的开发与验证
BMC Cancer. 2021 Feb 8;21(1):144. doi: 10.1186/s12885-021-07852-2.
7
Screening and identification of immune-related genes for immunotherapy and prognostic assessment in colorectal cancer patients.筛选和鉴定结直肠癌患者免疫治疗和预后评估的免疫相关基因。
BMC Med Genomics. 2022 Aug 8;15(1):177. doi: 10.1186/s12920-022-01329-2.
8
Development of a prognostic index based on an immunogenomic landscape analysis of papillary thyroid cancer.基于乳头状甲状腺癌免疫基因组图谱分析的预后指数的开发。
Aging (Albany NY). 2019 Jan 20;11(2):480-500. doi: 10.18632/aging.101754.
9
Development of prognostic signature based on immune-related genes in muscle-invasive bladder cancer: bioinformatics analysis of TCGA database.基于免疫相关基因的肌层浸润性膀胱癌预后标志物的构建：TCGA 数据库的生物信息学分析。
Aging (Albany NY). 2021 Jan 19;13(2):1859-1871. doi: 10.18632/aging.103787.
10
A Novel TGF-β Risk Score Predicts the Clinical Outcomes and Tumour Microenvironment Phenotypes in Bladder Cancer.一种新型 TGF-β 风险评分可预测膀胱癌的临床结局和肿瘤微环境表型。
Front Immunol. 2021 Dec 17;12:791924. doi: 10.3389/fimmu.2021.791924. eCollection 2021.

引用本文的文献

1
Integrative multi-omics and machine learning identify a robust signature for discriminating prognosis and therapeutic targets in bladder cancer.整合多组学和机器学习识别出用于区分膀胱癌预后和治疗靶点的强大特征。
J Cancer. 2025 Jan 27;16(5):1479-1503. doi: 10.7150/jca.105066. eCollection 2025.
2
[High expression of secretogranin II increases oxaliplatin resistance of colorectal cancer cells].分泌粒蛋白II的高表达增加结肠癌细胞对奥沙利铂的耐药性
Nan Fang Yi Ke Da Xue Xue Bao. 2023 Oct 20;43(10):1657-1664. doi: 10.12122/j.issn.1673-4254.2023.10.02.
3
A transcriptome study of p53-pathway related prognostic gene signature set in bladder cancer.

本文引用的文献

1
Identification of Microenvironment-Related Prognostic Genes in Bladder Cancer Based on Gene Expression Profile.基于基因表达谱的膀胱癌微环境相关预后基因的鉴定
Front Genet. 2019 Nov 22;10:1187. doi: 10.3389/fgene.2019.01187. eCollection 2019.
2
Systemic immune-inflammation index predicts prognosis of bladder cancer patients after radical cystectomy.全身免疫炎症指数可预测根治性膀胱切除术后膀胱癌患者的预后。
Ann Transl Med. 2019 Sep;7(18):431. doi: 10.21037/atm.2019.09.02.
3
A Consensus Molecular Classification of Muscle-invasive Bladder Cancer.
膀胱癌中p53信号通路相关预后基因特征集的转录组研究
Heliyon. 2023 Oct 14;9(10):e21058. doi: 10.1016/j.heliyon.2023.e21058. eCollection 2023 Oct.
4
Development of a prognostic signature for immune-associated genes in bladder cancer and exploring potential drug findings.开发用于膀胱癌免疫相关基因的预后特征，并探索潜在的药物发现。
Int Urol Nephrol. 2024 Feb;56(2):483-497. doi: 10.1007/s11255-023-03796-7. Epub 2023 Sep 23.
5
Expression pattern, tumor immune landscape, and prognostic value of N7‑methylguanosine regulators in bladder urothelial carcinoma.N7-甲基鸟苷调节剂在膀胱尿路上皮癌中的表达模式、肿瘤免疫景观及预后价值
Oncol Lett. 2023 Mar 10;25(4):169. doi: 10.3892/ol.2023.13755. eCollection 2023 Apr.
6
An epithelial-mesenchymal transition-related mRNA signature associated with the prognosis, immune infiltration and therapeutic response of colon adenocarcinoma.一个与结肠腺癌预后、免疫浸润和治疗反应相关的上皮-间充质转化相关 mRNA 特征。
Pathol Oncol Res. 2023 Feb 24;29:1611016. doi: 10.3389/pore.2023.1611016. eCollection 2023.
7
Clinical Significance and Tumor Microenvironment Characterization of a Novel Immune-Related Gene Signature in Bladder Cancer.膀胱癌中一种新型免疫相关基因特征的临床意义及肿瘤微环境特征分析
J Clin Med. 2023 Feb 27;12(5):1892. doi: 10.3390/jcm12051892.
8
Distinct immune and inflammatory response patterns contribute to the identification of poor prognosis and advanced clinical characters in bladder cancer patients.不同的免疫和炎症反应模式有助于识别膀胱癌患者的不良预后和晚期临床特征。
Front Immunol. 2022 Oct 27;13:1008865. doi: 10.3389/fimmu.2022.1008865. eCollection 2022.
9
Immune-related gene risk score predicting the effect of immunotherapy and prognosis in bladder cancer patients.免疫相关基因风险评分预测膀胱癌患者免疫治疗效果及预后
Front Genet. 2022 Oct 4;13:1011390. doi: 10.3389/fgene.2022.1011390. eCollection 2022.
10
Values of OAS gene family in the expression signature, immune cell infiltration and prognosis of human bladder cancer.OAS 基因家族在人类膀胱癌表达特征、免疫细胞浸润和预后中的价值。
BMC Cancer. 2022 Sep 26;22(1):1016. doi: 10.1186/s12885-022-10102-8.
肌肉浸润性膀胱癌的共识分子分类。
Eur Urol. 2020 Apr;77(4):420-433. doi: 10.1016/j.eururo.2019.09.006. Epub 2019 Sep 26.
4
Temporal changes within the (bladder) tumor microenvironment that accompany the therapeutic effects of the immunocytokine NHS-IL12.伴随免疫细胞因子 NHS-IL12 治疗效果的（膀胱）肿瘤微环境中的时变现象。
J Immunother Cancer. 2019 Jun 11;7(1):150. doi: 10.1186/s40425-019-0620-2.
5
Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data.通过 RNA-seq 数据解析揭示的肿瘤免疫微环境的分子和药理学调节剂。
Genome Med. 2019 May 24;11(1):34. doi: 10.1186/s13073-019-0638-6.
6
The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes.肿瘤免疫微环境驱动预后相关性，与膀胱癌亚型相关。
Cancer Immunol Res. 2019 Jun;7(6):923-938. doi: 10.1158/2326-6066.CIR-18-0758. Epub 2019 Apr 15.
7
Identification of a three-miRNA signature as a novel potential prognostic biomarker in patients with clear cell renal cell carcinoma.鉴定出一个三 miRNA 特征作为透明细胞肾细胞癌患者新的潜在预后生物标志物。
J Cell Biochem. 2019 Aug;120(8):13751-13764. doi: 10.1002/jcb.28648. Epub 2019 Apr 7.
8
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets.Metascape 为系统水平数据集的分析提供了面向生物学家的资源。
Nat Commun. 2019 Apr 3;10(1):1523. doi: 10.1038/s41467-019-09234-6.
9
OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug.OAS-RNase L 先天免疫途径介导 DNA 去甲基化药物的细胞毒性。
Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5071-5076. doi: 10.1073/pnas.1815071116. Epub 2019 Feb 27.
10
Recurrent Loss-of-Function Mutations Reveal Costs to OAS1 Antiviral Activity in Primates.反复出现的功能丧失突变揭示了 OAS1 抗病毒活性在灵长类动物中的代价。
Cell Host Microbe. 2019 Feb 13;25(2):336-343.e4. doi: 10.1016/j.chom.2019.01.001. Epub 2019 Jan 31.