Wahab P J, Rijnsburger A W, van der Veen E A, Heine R J
Diabetes Res Clin Pract. 1987 Jul-Aug;3(4):203-6. doi: 10.1016/s0168-8227(87)80040-2.
The influence of U 40 and U 100 insulin on the insulin kinetics during continuous subcutaneous insulin infusion (CSII) was investigated in eight insulin-dependent diabetics. CSII was started at t = -1.5 h with a bolus of 2 IU at the individual treatment infusion rate (22-35 IU/24 h), followed at t = 0 h by a premeal dose of 6 IU. Insulin delivery was interrupted for 120 min at t = 4 h and reinitiated with a loading dose of 2 IU for another 2 h. The incremental peak plasma free insulin levels and the time to reach these levels after the premeal insulin dose were not significantly different: 17 +/- 2 vs. 16 +/- 2 mU/l and 144 +/- 22 vs. 129 +/- 9 min for U 40 and U 100 insulin, respectively. During the 2 h interruption of insulin delivery plasma free insulin levels declined by 5.0 +/- 1.6 and 7.2 +/- 1.3 mU/l (NS) for U 40 and U 100 insulin, respectively. The blood glucose profiles were virtually identical throughout the studies for either insulin concentration. These results indicate that varying the insulin concentration in the range between U 40 and U 100 does not affect the insulin kinetics during CSII in insulin-dependent diabetics.
在8名胰岛素依赖型糖尿病患者中研究了U40和U100胰岛素对持续皮下胰岛素输注（CSII）期间胰岛素动力学的影响。CSII于t = -1.5小时开始，以个体治疗输注速率（22 - 35 IU/24小时）给予2 IU的推注剂量，随后在t = 0小时给予6 IU的餐前剂量。在t = 4小时时，胰岛素输注中断120分钟，然后以2 IU的负荷剂量重新开始输注2小时。餐前胰岛素剂量后血浆游离胰岛素水平的增量峰值及其达到这些水平的时间无显著差异：U40胰岛素和U100胰岛素分别为17±2与16±2 mU/l以及144±22与129±9分钟。在胰岛素输注中断的2小时内，U40胰岛素和U100胰岛素的血浆游离胰岛素水平分别下降了5.0±1.6和7.2±1.3 mU/l（无显著性差异）。在整个研究过程中，两种胰岛素浓度下的血糖谱几乎相同。这些结果表明，在U40和U100之间改变胰岛素浓度不会影响胰岛素依赖型糖尿病患者CSII期间的胰岛素动力学。
