Department of Nursing, Chung-Ang University, Seoul 06974, Korea.
Int J Environ Res Public Health. 2020 Oct 8;17(19):7348. doi: 10.3390/ijerph17197348.
The aim was to adapt and validate the Modified Transplant Symptom Occurrence and Symptom Distress Scale (MTSOSD-59R) for kidney transplant recipients undergoing immunosuppressive therapy in Korea. The MTSOSD-59R has been used with solid organ transplant recipients globally to assess the adverse effects of immunosuppressive medication. A descriptive cross-sectional design was used. MTSOSD-59R was first translated, and pilot tested. Next, content validity was established with nine organ transplant experts. Then, from October 2017 to October 2018, the Korean MTOSOSD-59R was administered to a convenience sample of 122 kidney transplant recipients recruited from a single center. Ridit analysis was used to measure symptom occurrence and distress. The known-group approach was used to test the construct validity using Mann-Whitney U tests for between-group comparisons. The content validity index for MTSOSD-59R was 0.98, and known-group validity was confirmed. The split-half Spearman-Brown corrected reliability coefficient was 0.902 for symptom occurrence and 0.893 for symptom distress. The four most frequent and distressing symptoms were fatigue, lack of energy, thinning hair, and erectile dysfunction (male). Results suggest this Korean MTSOSD-59R adaptation has adequate language, construct validity, and reliability to gather meaningful information from kidney transplant recipients in Korea.
本研究旨在改编并验证韩国接受免疫抑制治疗的肾移植受者使用的改良移植症状发生和症状困扰量表（MTSOSD-59R）。MTSOSD-59R 已在全球范围内用于评估实体器官移植受者免疫抑制药物的不良反应。本研究采用描述性的横断面设计。首先对 MTSOSD-59R 进行翻译和预试验，然后邀请 9 位器官移植专家进行内容效度评估。2017 年 10 月至 2018 年 10 月，从单中心招募 122 名肾移植受者，采用便利抽样的方法对韩国 MTSOSD-59R 进行调查。Ridit 分析用于测量症状发生和困扰的程度。采用 Mann-Whitney U 检验进行组间比较，以已知组法检验构念效度。MTSOSD-59R 的内容效度指数为 0.98，具有良好的构念效度。症状发生和症状困扰的分半 Spearman-Brown 校正信度系数分别为 0.902 和 0.893。最常见和最困扰的四个症状是疲劳、缺乏精力、脱发和勃起功能障碍（男性）。研究结果表明，韩国版 MTSOSD-59R 具有足够的语言、构念效度和信度，可以从韩国的肾移植受者中收集有意义的信息。
