Vassilopoulos D, Jockers-Wretou E
Eur Neurol. 1987;27(2):78-81. doi: 10.1159/000116135.
The creatine kinase B (CK-B) subunit was determined by our own highly sensitive solid-phase direct immunoassay in three neurological diseases which represent models of central nervous system (CNS) involvement: idiopathic epilepsy (18 patients), a disease characterised by a transient neuronal hyperactivity; Parkinson's disease (17 patients), a degenerative disorder of the CNS, and multiple sclerosis (21 patients), which represents a model of demyelination of the CNS. A group of 50 controls was also studied. The results showed that in patients with epilepsy and multiple sclerosis the CK-B activity was considerably lower than in the controls (p less than 0.01 and p less than 0.005, respectively), while no differences were found between the controls and the patients with Parkinson's disease. It is suggested that the low CK-B activity observed might be due to the medication taken or to the disease process itself. The present findings have to be considered as an indication for further CK isoenzyme studies in systematic disorders of the nervous system.
采用我们自己高度灵敏的固相直接免疫分析法，对三种代表中枢神经系统（CNS）受累模型的神经疾病患者的肌酸激酶B（CK-B）亚基进行了测定：特发性癫痫（18例患者），一种以短暂性神经元活动亢进为特征的疾病；帕金森病（17例患者），一种中枢神经系统退行性疾病；以及多发性硬化症（21例患者），它代表中枢神经系统脱髓鞘模型。还对一组50名对照者进行了研究。结果显示，癫痫患者和多发性硬化症患者的CK-B活性明显低于对照组（分别为p<0.01和p<0.005），而对照组与帕金森病患者之间未发现差异。提示观察到的低CK-B活性可能是由于所服用的药物或疾病过程本身所致。本研究结果应被视为在神经系统系统性疾病中进一步进行CK同工酶研究的一个指征。
