Jockers-Wretou E, Vassilopoulos D
J Neurol. 1985;232(4):236-9. doi: 10.1007/BF00313786.
This study is an attempt to determine the creatine kinase B (CK-B) subunit levels in neurogenic atrophies. A group of 69 patients was studied and the results were compared with those in a group of 32 patients with muscle disease. The results showed that the CK-B levels are considerably higher in patients with amyotrophic lateral sclerosis (P less than 0.001) and peroneal muscular atrophy (P less than 0.001). Further studies in the various subgroups of neurogenic atrophies showed that, regardless of the nosological entity, the CK-B activity is considerably higher: (1) in the "widespread" as opposed to "limited" forms (P less than 0.001); (2) in the "chronic" than in the "acute" neurogenic atrophies (P less than 0.001); and (3) in the "active" as opposed to "residual" forms (P less than 0.02). It is suggested that the increase of CK-B in neurogenic atrophies is a strong indication of an active regeneration process in the denervated muscle.
本研究旨在测定神经源性萎缩中肌酸激酶B（CK-B）亚基水平。对69例患者进行了研究，并将结果与32例肌肉疾病患者的结果进行了比较。结果显示，肌萎缩侧索硬化症患者（P<0.001）和腓骨肌萎缩症患者（P<0.001）的CK-B水平显著更高。对神经源性萎缩各亚组的进一步研究表明，无论病种如何，CK-B活性均显著更高：（1）“广泛”型与“局限”型相比（P<0.001）；（2）“慢性”神经源性萎缩比“急性”神经源性萎缩更高（P<0.001）；（3）“活动”型与“残留”型相比（P<0.02）。提示神经源性萎缩中CK-B升高强烈表明失神经肌肉存在活跃的再生过程。
