Andus T, Geiger T, Hirano T, Northoff H, Ganter U, Bauer J, Kishimoto T, Heinrich P C
FEBS Lett. 1987 Aug 31;221(1):18-22. doi: 10.1016/0014-5793(87)80344-7.
Conditioned medium from human monocytes contains a partially characterized hepatocyte-stimulating factor that simultaneously elevates the mRNA levels of the acute-phase protein beta-fibrinogen and decreases albumin mRNA in rat hepatoma cells. We demonstrate that recombinant human B-cell stimulatory factor 2, which is identical to interferon-beta 2/26 kDa protein and interleukin-HP1, exhibits the same activity as hepatocyte-stimulating factor. Furthermore, a specific antibody against B-cell stimulatory factor 2 was able to inhibit hepatocyte-stimulating factor in conditioned medium from human monocytes. Our data show that hepatocyte-stimulating factor and B-cell stimulatory factor 2 are functionally and immunologically related proteins.
来自人单核细胞的条件培养基含有一种部分特性已明确的肝细胞刺激因子，该因子能同时提高大鼠肝癌细胞中急性期蛋白β-纤维蛋白原的mRNA水平，并降低白蛋白mRNA水平。我们证明，重组人B细胞刺激因子2（与干扰素-β2/26 kDa蛋白和白细胞介素-HP1相同）具有与肝细胞刺激因子相同的活性。此外，一种针对B细胞刺激因子2的特异性抗体能够抑制人单核细胞条件培养基中的肝细胞刺激因子。我们的数据表明，肝细胞刺激因子和B细胞刺激因子2是功能和免疫相关的蛋白质。
