Borer K T
Growth. 1987 Spring;51(1):103-17.
Exercise accelerates somatic and skeletal growth in mature nondeprived hamsters and induces catch-up growth when food restriction during exercise is followed by ad libitum realimentation. The hypothesis that nutrient availability controls the rate of growth through changes in anabolic hormone release was tested through measurements of serum growth hormone (GH) and insulin concentrations at the same time of day in exercising and sedentary hamsters subjected to acute fasts, chronic food restriction, and to acute and prolonged realimentation. Concentrations of GH and insulin increased in ad libitum-fed exercising hamsters, but these increases were abolished by 12 and 4 h of fast, and restored by 4 and 2 h of refeeding, respectively. Four h of refeeding restored exercise-induced increases in serum GH, but not in serum insulin concentration in chronically food-restricted hamsters. During catch-up growth, the growth rate was double that of ad libitum fed exercising hamsters, but the increases in serum GH concentration in the two situations were similar. I conclude that increases in serum GH rather than in serum insulin concentration are the most probable determinant of exercise-induced growth and catch-up growth because they are relatively refractory to short-term nutritional perturbations.
运动可加速成熟且营养未受剥夺的仓鼠的躯体和骨骼生长，并且在运动期间进行食物限制后再随意进食时可诱导追赶生长。通过在同一天的同一时间测量进行运动和久坐不动的仓鼠在急性禁食、慢性食物限制以及急性和长期再进食情况下的血清生长激素（GH）和胰岛素浓度，对营养可用性通过合成代谢激素释放的变化来控制生长速率这一假说进行了检验。在随意进食的运动仓鼠中，GH和胰岛素浓度升高，但禁食12小时和4小时可消除这些升高，而再进食4小时和2小时则分别使其恢复。在慢性食物限制的仓鼠中，再进食4小时可恢复运动诱导的血清GH升高，但不能恢复血清胰岛素浓度升高。在追赶生长期间，生长速率是随意进食的运动仓鼠的两倍，但两种情况下血清GH浓度的升高相似。我得出结论，血清GH浓度升高而非血清胰岛素浓度升高是运动诱导生长和追赶生长最可能的决定因素，因为它们相对不易受到短期营养扰动的影响。
