Division of Pediatric Neurology, Faculty of Medicine, Ankara University, Ankara, Turkey.
Department of Pediatrics, Kütahya Parkhayat Hospital, Kütahya, Turkey.
Rev Invest Clin. 2020 Dec 22;72(6):380-385. doi: 10.24875/RIC.20000208.
In most countries, contrary to some disadvantages, such as pain, relatively higher cost, and poor adherence to treatment, intramuscular (IM) route is still the primary treatment method for Vitamin B12 (VB12) deficiency. In recent years, because of these difficulties, new treatment methods are being sought for VB12 deficiency.
We aimed to compare sublingual (SL) and IM routes of VB12 administration in children with VB12 deficiency and to compare the efficacy of methylcobalamin and cyanocobalamin therapy in these children.
This retrospective study comprised 129 patients with VB12 deficiency (serum Vitamin 12 level ≤ 200 pg/mL) aged 5-18 years. Based on the formulations of Vitamin 12, we divided the patients into three treatment groups as IM cyanocobalamin, SL cyanocobalamin, and SL methylcobalamin.
After Vitamin 12 therapy, serum Vitamin 12 levels increased significantly in all patients, and there was a statistically significant difference between the treatment groups (p < 0.05).
SL cyanocobalamin and methylcobalamin were found as effective as IM cyanocobalamin for children with Vitamin 12 deficiency in correcting serum Vitamin 12 level and hematologic abnormalities.
在大多数国家，尽管肌内（IM）途径存在一些缺点，如疼痛、相对较高的成本和治疗依从性差，但它仍然是治疗维生素 B12（VB12）缺乏症的主要方法。近年来，由于这些困难，人们正在寻找新的 VB12 缺乏症治疗方法。
我们旨在比较舌下（SL）和 IM 途径给予 VB12 治疗儿童 VB12 缺乏症，并比较甲钴胺和氰钴胺治疗这些儿童的疗效。
这项回顾性研究纳入了 129 名年龄在 5-18 岁、VB12 缺乏症（血清维生素 12 水平≤200pg/mL）的患者。根据维生素 12 的配方，我们将患者分为三组：肌内氰钴胺、SL 氰钴胺和 SL 甲钴胺。
在接受维生素 12 治疗后，所有患者的血清维生素 12 水平均显著升高，且治疗组之间存在统计学差异（p<0.05）。
SL 氰钴胺和甲钴胺与 IM 氰钴胺一样，对儿童 VB12 缺乏症纠正血清维生素 12 水平和血液学异常均有效。
